Anh N Diep
Overview
Explore the profile of Anh N Diep including associated specialties, affiliations and a list of published articles.
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14
Citations
506
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0
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Recent Articles
1.
Kummar S, Abdul Razak A, Laurie S, Glatt D, Kell S, Diep A, et al.
Cancer Res Commun
. 2024 Dec;
5(1):94-105.
PMID: 39651931
Purpose: In this phase 1 portion of a first-in-human phase 1/2a study (NCT05199272), 23ME-00610 was evaluated in participants with advanced solid malignancies to determine its safety, tolerability, pharmacokinetics (PK), and...
2.
Moon E, Mello S, Li C, Chi J, Thakkar K, Kirkland J, et al.
Nat Commun
. 2021 Jul;
12(1):4308.
PMID: 34262028
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes...
3.
Mehibel M, Xu Y, Li C, Moon E, Thakkar K, Diep A, et al.
J Clin Invest
. 2021 Jun;
131(11).
PMID: 34060485
Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficient) cells through...
4.
Miao Y, Thakkar K, Qian J, Kariolis M, Huang W, Nandagopal S, et al.
Clin Cancer Res
. 2021 May;
27(15):4435-4448.
PMID: 34011561
Purpose: Ovarian cancer represents a major clinical hurdle for immune checkpoint blockade (ICB), with reported low patient response rates. We found that the immune checkpoint ligand PD-L2 is robustly expressed...
5.
Xiao Y, Thakkar K, Zhao H, Broughton J, Li Y, Seoane J, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21441-21449.
PMID: 32817424
Loss of the von Hippel-Lindau (VHL) tumor suppressor is a hallmark feature of renal clear cell carcinoma. VHL inactivation results in the constitutive activation of the hypoxia-inducible factors (HIFs) HIF-1...
6.
Xiao Y, Zhao H, Tian L, Nolley R, Diep A, Ernst A, et al.
Cancer Res
. 2019 Oct;
79(22):5758-5768.
PMID: 31585940
Angiogenesis is a hallmark of cancer that promotes tumor progression and metastasis. However, antiangiogenic agents have limited efficacy in cancer therapy due to the development of resistance. In clear cell...
7.
Benninger M, Diep A, Kaplan S
Laryngoscope
. 2019 Feb;
129(11):2557-2562.
PMID: 30715726
Objectives: The application of laser (light amplification by stimulated emission of radiation) energy in the larynx relies on thermal injury. The impact of this injury on adjacent tissue can be...
8.
Rankin E, Fuh K, Castellini L, Viswanathan K, Finger E, Diep A, et al.
Proc Natl Acad Sci U S A
. 2014 Sep;
111(37):13373-8.
PMID: 25187556
Dysregulation of the von Hippel-Lindau/hypoxia-inducible transcription factor (HIF) signaling pathway promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis. The protein kinase GAS6/AXL signaling pathway has recently been implicated...
9.
Taniguchi C, Miao Y, Diep A, Wu C, Rankin E, Atwood T, et al.
Sci Transl Med
. 2014 May;
6(236):236ra64.
PMID: 24828078
Radiation-induced gastrointestinal (GI) toxicity can be a major source of morbidity and mortality after radiation exposure. There is an unmet need for effective preventative or mitigative treatments against the potentially...
10.
Taniguchi C, Finger E, Krieg A, Wu C, Diep A, LaGory E, et al.
Nat Med
. 2013 Sep;
19(10):1325-30.
PMID: 24037093
Signaling initiated by hypoxia and insulin powerfully alters cellular metabolism. The protein stability of hypoxia-inducible factor-1 alpha (Hif-1α) and Hif-2α is regulated by three prolyl hydroxylase domain-containing protein isoforms (Phd1,...