Adam J Krieg
Overview
Explore the profile of Adam J Krieg including associated specialties, affiliations and a list of published articles.
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24
Citations
1089
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0
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Recent Articles
1.
Qiu L, Meng Y, Wang L, Gunewardena S, Liu S, Han J, et al.
MedComm (2020)
. 2021 Nov;
2(3):414-429.
PMID: 34766154
The hypoxic tumor microenvironment promotes tumor survival by inducing the expression of genes involved in angiogenesis and metastasis. As a direct target of hypoxia-inducible factor, lysine demethylase 4B () is...
2.
Moon E, Mello S, Li C, Chi J, Thakkar K, Kirkland J, et al.
Nat Commun
. 2021 Jul;
12(1):4308.
PMID: 34262028
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes...
3.
Pejovic T, McCluggage W, Krieg A, Xu F, Lee D, Witkowski L, et al.
Gynecol Oncol Rep
. 2019 Mar;
28:47-49.
PMID: 30886884
•New pathogenic familial variant, c.3081+1G>T.•Prophylactic surgery in healthy carrier of germline mutation.•Long term hormone therapy in a 13-year-old girl.
4.
Natarajan S, Foreman K, Soriano M, Rossen N, Shehade H, Fregoso D, et al.
Cancer Res
. 2019 Mar;
79(9):2271-2284.
PMID: 30862717
Peritoneal metastases are the leading cause of morbidity and mortality in high-grade serous ovarian cancer (HGSOC). Accumulating evidence suggests that mesothelial cells are an important component of the metastatic microenvironment...
5.
Wilson C, Krieg A
Genes (Basel)
. 2019 Feb;
10(2).
PMID: 30759871
Epigenetic changes are well-established contributors to cancer progression and normal developmental processes. The reversible modification of histones plays a central role in regulating the nuclear processes of gene transcription, DNA...
6.
Hirst J, Pathak H, Hyter S, Pessetto Z, Ly T, Graw S, et al.
Cancer Res
. 2018 Jun;
78(15):4370-4385.
PMID: 29891506
Drug development for first-line treatment of epithelial ovarian cancer (EOC) has been stagnant for almost three decades. Traditional cell culture methods for primary drug screening do not always accurately reflect...
7.
Krieg A, Mullinax S, Grimstad F, Marquis K, Constance E, Hong Y, et al.
J Assist Reprod Genet
. 2018 Mar;
35(6):993-1003.
PMID: 29536385
Purpose: To assess expression of the histone demethylases KDM4A and KDM4B in granulosa collected from women undergoing oocyte retrieval and to determine if expression was related to pregnancy outcome. Methods:...
8.
Dobrynin G, McAllister T, Leszczynska K, Ramachandran S, Krieg A, Kawamura A, et al.
Sci Rep
. 2017 Sep;
7(1):11094.
PMID: 28894274
Regions of hypoxia (low oxygen) occur in most solid tumours and cells in these areas are the most aggressive and therapy resistant. In response to decreased oxygen, extensive changes in...
9.
Padro M, Louie R, Lananna B, Krieg A, Timmerman L, Chan D
BMC Cancer
. 2017 Mar;
17(1):203.
PMID: 28320353
Background: About 75-80% of breast tumors express the estrogen receptor alpha (ER-α) and are treated with endocrine-target therapeutics, making this the premier therapeutic modality in the breast cancer clinic. However,...
10.
Castellini L, Moon E, Razorenova O, Krieg A, von Eyben R, Giaccia A
Nucleic Acids Res
. 2017 Jan;
45(7):3674-3692.
PMID: 28073943
The p53 tumor suppressor protein plays a critical role in orchestrating the genomic response to various stress signals by acting as a master transcriptional regulator. Differential gene activity is controlled...