Edward L LaGory
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Explore the profile of Edward L LaGory including associated specialties, affiliations and a list of published articles.
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26
Citations
1106
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Recent Articles
1.
Cho Y, Cao Z, Luo X, Tian J, Hukkanen R, Hussien R, et al.
Cell Death Dis
. 2024 Oct;
15(10):759.
PMID: 39424623
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder characterized by disrupted epidermal barrier function and aberrant immune responses. Despite recent developments in new therapeutics for AD, there is...
2.
Devanaboyina S, Li P, LaGory E, Poon-Andersen C, Cook K, Soto M, et al.
MAbs
. 2024 Jul;
16(1):2383013.
PMID: 39051531
Targeting antigens with antibodies exhibiting pH/Ca-dependent binding against an antigen is an attractive strategy to mitigate target-mediated disposition and antigen buffering. Studies have reported improved serum exposure of antibodies exhibiting...
3.
Bryniarski M, Tuhin M, Acker T, Wakefield D, Sethaputra P, Cook K, et al.
J Pharm Sci
. 2024 Jun;
113(9):2879-2894.
PMID: 38906252
In vivo clearance mechanisms of therapeutic monoclonal antibodies (mAbs) encompass both target-mediated and target-independent processes. Two distinct determinants of overall mAb clearance largely separate of target-mediated influences are non-specific cellular...
4.
Guo Y, Gao Z, LaGory E, Kristin L, Gupte J, Gong Y, et al.
Hepatol Commun
. 2024 May;
8(5).
PMID: 38696369
Background: Human genetic studies have identified several mitochondrial amidoxime-reducing component 1 (MTARC1) variants as protective against metabolic dysfunction-associated steatotic liver disease. The MTARC1 variants are associated with decreased plasma lipids...
5.
Kudo T, Zhao M, Jeknic S, Kovary K, LaGory E, Covert M, et al.
Cell Syst
. 2023 Nov;
14(12):1074-1086.e7.
PMID: 37995680
Hypoxia-induced upregulation of HIF1α triggers adipose tissue dysfunction and insulin resistance in obese patients. HIF1α closely interacts with PPARγ, the master regulator of adipocyte differentiation and lipid accumulation, but there...
6.
Klasson T, LaGory E, Zhao H, Huynh S, Papandreou I, Moon E, et al.
Cancer Metab
. 2022 Oct;
10(1):14.
PMID: 36192773
Background: Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. However, the pathways...
7.
Jiang Z, Elsarrag S, Duan Q, LaGory E, Wang Z, Alexanian M, et al.
Sci Adv
. 2022 Mar;
8(10):eabj2917.
PMID: 35263131
Circulating corticosteroids orchestrate stress adaptation, including inhibition of inflammation. While pathways governing corticosteroid biosynthesis and intracellular signaling are well understood, less is known about mechanisms controlling plasma corticosteroid transport. Here,...
8.
Moon E, Mello S, Li C, Chi J, Thakkar K, Kirkland J, et al.
Nat Commun
. 2021 Jul;
12(1):4308.
PMID: 34262028
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes...
9.
Chang A, Pardon G, Chang A, Wu H, Ong S, Eguchi A, et al.
Stem Cell Reports
. 2021 May;
16(9):2169-2181.
PMID: 34019816
Duchenne muscular dystrophy (DMD) is a rare X-linked recessive disease that is associated with severe progressive muscle degeneration culminating in death due to cardiorespiratory failure. We previously observed an unexpected...
10.
Cui L, Gouw A, LaGory E, Guo S, Attarwala N, Tang Y, et al.
Nat Biotechnol
. 2020 Oct;
39(3):357-367.
PMID: 33077961
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing...