Amato J Giaccia
Overview
Explore the profile of Amato J Giaccia including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
217
Citations
13982
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Bouchard G, Zhang W, Ilerten I, Li I, Bhattacharya A, Li Y, et al.
Nat Commun
. 2025 Feb;
16(1):1392.
PMID: 39915493
Spatial omics is enabling unprecedented tissue characterization, but the ability to adequately compare spatial features across samples under different conditions is lacking. We propose a quantitative framework that catalogs significant,...
2.
Chiu C, Zhang D, Zhao H, Wei Y, Polasko A, Thomsen M, et al.
Clin Cancer Res
. 2025 Jan;
PMID: 39879384
Purpose: After failing primary and secondary hormonal therapy, castration-resistant and neuroendocrine prostate cancer metastatic to the bone is invariably lethal, although treatment with docetaxel and carboplatin can modestly improve survival....
3.
Estephan H, Tailor A, Parker R, Kreamer M, Papandreou I, Campo L, et al.
EMBO J
. 2025 Jan;
44(3):903-922.
PMID: 39753950
Hypoxia is a common feature of solid tumors that has previously been linked to resistance to radiotherapy and chemotherapy, and more recently to immunotherapy. In particular, hypoxic tumors exclude T...
4.
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar D, Kim R, et al.
J Clin Invest
. 2024 Aug;
134(16).
PMID: 39145459
No abstract available.
5.
Miao Y, Rankin E, Giaccia A
Nat Rev Drug Discov
. 2023 Dec;
23(3):201-217.
PMID: 38092952
The TAM receptor family of TYRO3, AXL and MERTK regulates tissue and immune homeostasis. Aberrant TAM receptor signalling has been linked to a range of diseases, including cancer, fibrosis and...
6.
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar D, Kim R, et al.
J Clin Invest
. 2023 Oct;
133(23).
PMID: 37824211
An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still...
7.
Bouchard G, Zhang W, Li I, Ilerten I, Bhattacharya A, Li Y, et al.
bioRxiv
. 2023 Sep;
PMID: 37745466
Computational frameworks to quantify and compare microenvironment spatial features of in-vitro patient-derived models and clinical specimens are needed. Here, we acquired and analysed multiplexed immunofluorescence images of human lung adenocarcinoma...
8.
Chiu C, Li C, Verschueren E, Wen R, Zhang D, Gordon C, et al.
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047232
Increased expression of NUSAP1 has been identified as a robust prognostic biomarker in prostate cancer and other malignancies. We have previously shown that NUSAP1 is positively regulated by E2F1 and...
9.
Leszczynska K, Dzwigonska M, Estephan H, Moehlenbrink J, Bowler E, Giaccia A, et al.
Mol Oncol
. 2023 Apr;
17(7):1173-1191.
PMID: 37013907
Local hypoxia occurs in most solid tumors and is associated with aggressive disease and therapy resistance. Widespread changes in gene expression play a critical role in the biological response to...
10.
Klasson T, LaGory E, Zhao H, Huynh S, Papandreou I, Moon E, et al.
Cancer Metab
. 2022 Oct;
10(1):14.
PMID: 36192773
Background: Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple metabolic pathways, including the accumulation of cytosolic lipid droplets. However, the pathways...