Andrew R Griswold
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Explore the profile of Andrew R Griswold including associated specialties, affiliations and a list of published articles.
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15
Citations
625
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Recent Articles
1.
Orth-He E, Huang H, Rao S, Wang Q, Chen Q, OMara C, et al.
Cell Rep
. 2023 Jan;
42(1):111965.
PMID: 36649711
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-terminal (NT) and C-terminal (CT) fragments. The proteasome-mediated degradation of...
2.
Ball D, Tsamouri L, Wang A, Huang H, Warren C, Wang Q, et al.
Sci Immunol
. 2022 Nov;
7(77):eabm7200.
PMID: 36332009
The danger signals that activate the NLRP1 inflammasome have not been established. Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to NLRP1. We...
3.
Students as Community Vaccinators: Implementation of A Service-Learning COVID-19 Vaccination Program
Griswold A, Klein J, Dusaj N, Zhu J, Keeler A, Abramson E, et al.
Vaccines (Basel)
. 2022 Jul;
10(7).
PMID: 35891222
While the COVID-19 pandemic has caused major educational disruptions, it has also catalyzed innovation in service-learning as a real-time response to pandemic-related problems. The limited number of qualified providers was...
4.
Hsiao J, Neugroschl A, Chui A, Taabazuing C, Griswold A, Wang Q, et al.
J Biol Chem
. 2022 May;
298(7):102032.
PMID: 35580636
CARD8 is a pattern-recognition receptor that forms a caspase-1-activating inflammasome. CARD8 undergoes constitutive autoproteolysis, generating an N-terminal (NT) fragment with a disordered region and a ZU5 domain and a C-terminal...
5.
Griswold A, Huang H, Bachovchin D
Invest Ophthalmol Vis Sci
. 2022 Mar;
63(3):2.
PMID: 35238869
Purpose: Inflammasomes are multiprotein complexes that detect danger-associated signals and trigger an immunostimulatory form of cell death called pyroptosis. NLRP1 is an innate immune receptor that assembles into an inflammasome,...
6.
Rao S, Chen Q, Wang Q, Orth-He E, Saoi M, Griswold A, et al.
Nat Chem Biol
. 2022 Feb;
18(5):565-574.
PMID: 35165443
Inflammasomes are multiprotein complexes that sense intracellular danger signals and induce pyroptosis. CARD8 and NLRP1 are related inflammasomes that are repressed by the enzymatic activities and protein structures of the...
7.
Sharif H, Hollingsworth L, Griswold A, Hsiao J, Wang Q, Bachovchin D, et al.
Immunity
. 2021 May;
54(7):1392-1404.e10.
PMID: 34019797
CARD8 detects intracellular danger signals and forms a caspase-1 activating inflammasome. Like the related inflammasome sensor NLRP1, CARD8 autoprocesses into noncovalently associated N-terminal (NT) and C-terminal (CT) fragments and binds...
8.
Hollingsworth L, Sharif H, Griswold A, Fontana P, Mintseris J, Dagbay K, et al.
Nature
. 2021 Mar;
592(7856):778-783.
PMID: 33731932
Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1) is an inflammasome sensor that mediates the activation of caspase-1 to induce cytokine maturation and pyroptosis. Gain-of-function mutations of NLRP1...
9.
Hollingsworth L, David L, Li Y, Griswold A, Ruan J, Sharif H, et al.
Nat Commun
. 2021 Jan;
12(1):189.
PMID: 33420033
NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase-1 activation, cytokine maturation and/or pyroptotic cell death. NLRP1 and...
10.
Chui A, Griswold A, Taabazuing C, Orth E, Gai K, Rao S, et al.
Cell Rep
. 2020 Oct;
33(2):108264.
PMID: 33053349
Several cytosolic pattern-recognition receptors (PRRs) form multiprotein complexes called canonical inflammasomes in response to intracellular danger signals. Canonical inflammasomes recruit and activate caspase-1 (CASP1), which in turn cleaves and activates...