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Elizabeth L Orth

Explore the profile of Elizabeth L Orth including associated specialties, affiliations and a list of published articles. Areas
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Citations 307
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Recent Articles
1.
Chui A, Griswold A, Taabazuing C, Orth E, Gai K, Rao S, et al.
Cell Rep . 2020 Oct; 33(2):108264. PMID: 33053349
Several cytosolic pattern-recognition receptors (PRRs) form multiprotein complexes called canonical inflammasomes in response to intracellular danger signals. Canonical inflammasomes recruit and activate caspase-1 (CASP1), which in turn cleaves and activates...
2.
Johnson D, Okondo M, Orth E, Rao S, Huang H, Ball D, et al.
Cell Death Dis . 2020 Aug; 11(8):628. PMID: 32796818
Canonical inflammasomes are innate immune signaling platforms that are formed in response to intracellular pathogen-associated signals and trigger caspase-1-dependent pyroptosis. Inflammasome formation and signaling is thought to mainly occur in...
3.
Ball D, Taabazuing C, Griswold A, Orth E, Rao S, Kotliar I, et al.
Life Sci Alliance . 2020 Feb; 3(3). PMID: 32051255
Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs) to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell death. All well-studied inflammasome-forming PRRs oligomerize with the adapter...
4.
Chui A, Okondo M, Rao S, Gai K, Griswold A, Johnson D, et al.
Science . 2019 Mar; 364(6435):82-85. PMID: 30872531
Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors both activate the NLRP1B...