Elizabeth L Orth-He
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Explore the profile of Elizabeth L Orth-He including associated specialties, affiliations and a list of published articles.
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6
Citations
89
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Recent Articles
1.
Chen Q, Wang A, Covelli D, Bhattacharjee A, Wang Q, Orth-He E, et al.
J Med Chem
. 2023 Feb;
66(4):2589-2607.
PMID: 36724486
Inflammasomes are innate immune signaling platforms that trigger pyroptotic cell death. NLRP1 and CARD8 are related human inflammasomes that detect similar danger signals, but NLRP1 has a higher activation threshold...
2.
Orth-He E, Huang H, Rao S, Wang Q, Chen Q, OMara C, et al.
Cell Rep
. 2023 Jan;
42(1):111965.
PMID: 36649711
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-terminal (NT) and C-terminal (CT) fragments. The proteasome-mediated degradation of...
3.
Wang Q, Hsiao J, Yardeny N, Huang H, OMara C, Orth-He E, et al.
Cell Rep
. 2023 Jan;
42(1):111966.
PMID: 36649710
The danger signals that activate the related nucleotide-binding domain leucine-rich repeat pyrin domain-containing 1 (NLRP1) and caspase activation and recruitment domain-containing 8 (CARD8) inflammasomes have not been fully established. We...
4.
Hsiao J, Neugroschl A, Chui A, Taabazuing C, Griswold A, Wang Q, et al.
J Biol Chem
. 2022 May;
298(7):102032.
PMID: 35580636
CARD8 is a pattern-recognition receptor that forms a caspase-1-activating inflammasome. CARD8 undergoes constitutive autoproteolysis, generating an N-terminal (NT) fragment with a disordered region and a ZU5 domain and a C-terminal...
5.
Rao S, Chen Q, Wang Q, Orth-He E, Saoi M, Griswold A, et al.
Nat Chem Biol
. 2022 Feb;
18(5):565-574.
PMID: 35165443
Inflammasomes are multiprotein complexes that sense intracellular danger signals and induce pyroptosis. CARD8 and NLRP1 are related inflammasomes that are repressed by the enzymatic activities and protein structures of the...
6.
Hollingsworth L, David L, Li Y, Griswold A, Ruan J, Sharif H, et al.
Nat Commun
. 2021 Jan;
12(1):189.
PMID: 33420033
NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase-1 activation, cytokine maturation and/or pyroptotic cell death. NLRP1 and...