Daniel P Ball
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Explore the profile of Daniel P Ball including associated specialties, affiliations and a list of published articles.
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21
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596
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Recent Articles
1.
Tsamouri L, Hsiao J, Wang Q, Geeson M, Huang H, Nambiar D, et al.
Cell Chem Biol
. 2024 Jul;
31(9):1699-1713.e8.
PMID: 38991619
Mounting evidence indicates that proteotoxic stress is a primary activator of the CARD8 inflammasome, but the complete array of signals that control this inflammasome have not yet been established. Notably,...
2.
Geeson M, Hsiao J, Tsamouri L, Ball D, Bachovchin D
Cell Chem Biol
. 2024 Jan;
31(5):955-961.e4.
PMID: 38215746
NLRP1 is an innate immune receptor that detects pathogen-associated signals, assembles into a multiprotein structure called an inflammasome, and triggers a proinflammatory form of cell death called pyroptosis. We previously...
3.
Geeson M, Hsiao J, Tsamouri L, Ball D, Bachovchin D
bioRxiv
. 2023 Oct;
PMID: 37808697
NLRP1 is an innate immune receptor that detects pathogen-associated signals, assembles into a multiprotein structure called an inflammasome, and triggers a proinflammatory form of cell death called pyroptosis. We previously...
4.
Chen Q, Wang A, Covelli D, Bhattacharjee A, Wang Q, Orth-He E, et al.
J Med Chem
. 2023 Feb;
66(4):2589-2607.
PMID: 36724486
Inflammasomes are innate immune signaling platforms that trigger pyroptotic cell death. NLRP1 and CARD8 are related human inflammasomes that detect similar danger signals, but NLRP1 has a higher activation threshold...
5.
Orth-He E, Huang H, Rao S, Wang Q, Chen Q, OMara C, et al.
Cell Rep
. 2023 Jan;
42(1):111965.
PMID: 36649711
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-terminal (NT) and C-terminal (CT) fragments. The proteasome-mediated degradation of...
6.
Wang Q, Hsiao J, Yardeny N, Huang H, OMara C, Orth-He E, et al.
Cell Rep
. 2023 Jan;
42(1):111966.
PMID: 36649710
The danger signals that activate the related nucleotide-binding domain leucine-rich repeat pyrin domain-containing 1 (NLRP1) and caspase activation and recruitment domain-containing 8 (CARD8) inflammasomes have not been fully established. We...
7.
Ball D, Tsamouri L, Wang A, Huang H, Warren C, Wang Q, et al.
Sci Immunol
. 2022 Nov;
7(77):eabm7200.
PMID: 36332009
The danger signals that activate the NLRP1 inflammasome have not been established. Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to NLRP1. We...
8.
Hsiao J, Neugroschl A, Chui A, Taabazuing C, Griswold A, Wang Q, et al.
J Biol Chem
. 2022 May;
298(7):102032.
PMID: 35580636
CARD8 is a pattern-recognition receptor that forms a caspase-1-activating inflammasome. CARD8 undergoes constitutive autoproteolysis, generating an N-terminal (NT) fragment with a disordered region and a ZU5 domain and a C-terminal...
9.
Rao S, Chen Q, Wang Q, Orth-He E, Saoi M, Griswold A, et al.
Nat Chem Biol
. 2022 Feb;
18(5):565-574.
PMID: 35165443
Inflammasomes are multiprotein complexes that sense intracellular danger signals and induce pyroptosis. CARD8 and NLRP1 are related inflammasomes that are repressed by the enzymatic activities and protein structures of the...
10.
Chui A, Griswold A, Taabazuing C, Orth E, Gai K, Rao S, et al.
Cell Rep
. 2020 Oct;
33(2):108264.
PMID: 33053349
Several cytosolic pattern-recognition receptors (PRRs) form multiprotein complexes called canonical inflammasomes in response to intracellular danger signals. Canonical inflammasomes recruit and activate caspase-1 (CASP1), which in turn cleaves and activates...