Daniel A Bachovchin
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Explore the profile of Daniel A Bachovchin including associated specialties, affiliations and a list of published articles.
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54
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Recent Articles
1.
Tsamouri L, Hsiao J, Bachovchin D
J Biol Chem
. 2024 Nov;
301(1):108034.
PMID: 39615677
Synthetic inhibitors of the serine protease DPP9 activate the related NLRP1 and CARD8 inflammasomes and stimulate powerful innate immune responses. Thus, it seems plausible that a biomolecule similarly inhibits DPP9...
2.
Tsamouri L, Hsiao J, Wang Q, Geeson M, Huang H, Nambiar D, et al.
Cell Chem Biol
. 2024 Jul;
31(9):1699-1713.e8.
PMID: 38991619
Mounting evidence indicates that proteotoxic stress is a primary activator of the CARD8 inflammasome, but the complete array of signals that control this inflammasome have not yet been established. Notably,...
3.
Geeson M, Hsiao J, Tsamouri L, Ball D, Bachovchin D
Cell Chem Biol
. 2024 Jan;
31(5):955-961.e4.
PMID: 38215746
NLRP1 is an innate immune receptor that detects pathogen-associated signals, assembles into a multiprotein structure called an inflammasome, and triggers a proinflammatory form of cell death called pyroptosis. We previously...
4.
Bhattacharjee A, Bachovchin D
Isr J Chem
. 2023 Nov;
63(3-4).
PMID: 37982048
Small molecule inhibitors of the intracellular serine peptidases DPP8 and DPP9 (DPP8/9) activate the NLRP1 and CARD8 inflammasomes, but the key DPP8/9 substrates have not yet been identified. DPP8/9 cleave...
5.
Geeson M, Hsiao J, Tsamouri L, Ball D, Bachovchin D
bioRxiv
. 2023 Oct;
PMID: 37808697
NLRP1 is an innate immune receptor that detects pathogen-associated signals, assembles into a multiprotein structure called an inflammasome, and triggers a proinflammatory form of cell death called pyroptosis. We previously...
6.
Chen Q, Wang A, Covelli D, Bhattacharjee A, Wang Q, Orth-He E, et al.
J Med Chem
. 2023 Feb;
66(4):2589-2607.
PMID: 36724486
Inflammasomes are innate immune signaling platforms that trigger pyroptotic cell death. NLRP1 and CARD8 are related human inflammasomes that detect similar danger signals, but NLRP1 has a higher activation threshold...
7.
Orth-He E, Huang H, Rao S, Wang Q, Chen Q, OMara C, et al.
Cell Rep
. 2023 Jan;
42(1):111965.
PMID: 36649711
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-terminal (NT) and C-terminal (CT) fragments. The proteasome-mediated degradation of...
8.
Wang Q, Hsiao J, Yardeny N, Huang H, OMara C, Orth-He E, et al.
Cell Rep
. 2023 Jan;
42(1):111966.
PMID: 36649710
The danger signals that activate the related nucleotide-binding domain leucine-rich repeat pyrin domain-containing 1 (NLRP1) and caspase activation and recruitment domain-containing 8 (CARD8) inflammasomes have not been fully established. We...
9.
Ball D, Tsamouri L, Wang A, Huang H, Warren C, Wang Q, et al.
Sci Immunol
. 2022 Nov;
7(77):eabm7200.
PMID: 36332009
The danger signals that activate the NLRP1 inflammasome have not been established. Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to NLRP1. We...
10.
Volpe M, Velilla J, Daniel-Ivad M, Yao J, Stornetta A, Villalta P, et al.
Nat Chem Biol
. 2022 Oct;
19(2):159-167.
PMID: 36253549
The human gut bacterial genotoxin colibactin is a possible key driver of colorectal cancer (CRC) development. Understanding colibactin's biological effects remains difficult owing to the instability of the proposed active...