Andrew C Adey
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Explore the profile of Andrew C Adey including associated specialties, affiliations and a list of published articles.
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30
Citations
1364
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Recent Articles
1.
Link J, Eng J, Pelz C, MacPherson-Hawthorne K, Worth P, Sivagnanam S, et al.
Nat Cancer
. 2025 Jan;
6(1):123-144.
PMID: 39789181
Patients with metastatic pancreatic ductal adenocarcinoma survive longer if disease spreads to the lung but not the liver. Here we generated overlapping, multi-omic datasets to identify molecular and cellular features...
2.
Nichols R, Rylaarsdam L, OConnell B, Shipony Z, Iremadze N, Acharya S, et al.
Cell Genom
. 2024 Dec;
5(1):100726.
PMID: 39719707
Single-cell methods to assess DNA methylation have not achieved the same level of cell throughput per experiment compared to other modalities, with large-scale datasets requiring extensive automation, time, and other...
3.
Ak C, Sayar Z, Thibault G, Burlingame E, Kuykendall M, Eng J, et al.
iScience
. 2024 Sep;
27(9):110668.
PMID: 39246442
Mapping the spatial interactions of cancer, immune, and stromal cell states presents novel opportunities for patient stratification and for advancing immunotherapy. While single-cell studies revealed significant molecular heterogeneity in prostate...
4.
Rylaarsdam L, Nichols R, OConnell B, Coleman S, Yardimci G, Adey A
bioRxiv
. 2024 Aug;
PMID: 39211069
Single-cell sequencing technologies have revolutionized biomedical research by enabling deconvolution of cell type-specific properties in highly heterogeneous tissue. While robust tools have been developed to handle bioinformatic challenges posed by...
5.
Acharya S, Nichols R, Rylaarsdam L, OConnell B, Braun T, Adey A
Genome Biol
. 2024 Jul;
25(1):186.
PMID: 38987810
DNA methylation is a key component of the mammalian epigenome, playing a regulatory role in development, disease, and other processes. Robust, high-throughput single-cell DNA methylation assays are now possible (sciMET);...
6.
Zhang H, Mulqueen R, Iannuzo N, Farrera D, Polverino F, Galligan J, et al.
Genome Biol
. 2024 Mar;
25(1):78.
PMID: 38519979
We develop a large-scale single-cell ATAC-seq method by combining Tn5-based pre-indexing with 10× Genomics barcoding, enabling the indexing of up to 200,000 nuclei across multiple samples in a single reaction....
7.
Adey A
Cell Rep Methods
. 2023 Nov;
3(11):100648.
PMID: 37989084
In this Q&A, Scientific Editor Emily Marcinkevicius talks with author Andrew Adey about developing a more broadly accessible method for paired whole-genome and chromatin accessibility sequencing from single cells, as...
8.
Queitsch K, Moore T, OConnell B, Nichols R, Muschler J, Keith D, et al.
Cell Rep Methods
. 2023 Nov;
3(11):100625.
PMID: 37918402
Single-cell whole-genome sequencing (scWGS) enables the assessment of genome-level molecular differences between individual cells with particular relevance to genetically diverse systems like solid tumors. The application of scWGS was limited...
9.
De Rop F, Hulselmans G, Flerin C, Soler-Vila P, Rafels A, Christiaens V, et al.
Nat Biotechnol
. 2023 Aug;
42(6):916-926.
PMID: 37537502
Single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has emerged as a powerful tool for dissecting regulatory landscapes and cellular heterogeneity. However, an exploration of systemic biases among scATAC-seq technologies...
10.
Acharya S, Nichols R, Rylaarsdam L, OConnell B, Braun T, Adey A
bioRxiv
. 2023 Jul;
PMID: 37502923
DNA methylation is a key component of the mammalian epigenome, playing a regulatory role in development, disease, and other processes. Robust, high-throughput single-cell DNA methylation assays are now possible (sciMET);...