Jay Shendure
Overview
Explore the profile of Jay Shendure including associated specialties, affiliations and a list of published articles.
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405
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52146
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Recent Articles
1.
Rostomily C, Lee H, Tresenrider A, Daza R, Mullen A, Shendure J, et al.
Zebrafish
. 2025 Mar;
PMID: 40040474
Zebrafish is an ideal system to study the effect(s) of chemical, genetic, and environmental perturbations on development due to their high fecundity and fast growth. Recently, single-cell sequencing has emerged...
2.
Fang H, Tronco A, Bonora G, Nguyen T, Thakur J, Berletch J, et al.
BMC Biol
. 2025 Mar;
23(1):68.
PMID: 40025499
Background: Genes that escape X-chromosome inactivation (XCI) in female somatic cells vary in number and levels of escape among mammalian species and tissues, potentially contributing to species- and tissue-specific sex...
3.
Zhang R, Yang M, Schreiber J, ODay D, Turner J, Shendure J, et al.
Genome Biol
. 2025 Feb;
26(1):40.
PMID: 40012008
Cross-species comparison and prediction of gene expression profiles are important to understand regulatory changes during evolution and to transfer knowledge learned from model organisms to humans. Single-cell RNA-seq (scRNA-seq) profiles...
4.
Choi J, Chen W, Liao H, Li X, Shendure J
Elife
. 2025 Feb;
13.
PMID: 39937081
One of the goals of synthetic biology is to enable the design of arbitrary molecular circuits with programmable inputs and outputs. Such circuits bridge the properties of electronic and natural...
5.
Suiter C, Calderon D, Lee D, Chiu M, Jain S, Chardon F, et al.
Mol Cell
. 2025 Feb;
85(4):829-842.e6.
PMID: 39919746
E3 ubiquitin ligases (E3s) confer specificity of protein degradation through ubiquitination of substrate proteins. Yet, the vast majority of the >600 human E3s have no known substrates. To identify proteolytic...
6.
Pinglay S, Lalanne J, Daza R, Kottapalli S, Quaisar F, Koeppel J, et al.
Science
. 2025 Jan;
387(6733):eado5978.
PMID: 39883753
Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) methods to...
7.
Lalanne J, Mich J, Huynh C, Hunker A, McDiarmid T, Levi B, et al.
bioRxiv
. 2025 Jan;
PMID: 39868341
Adeno-associated viruses (AAVs) have emerged as the foremost gene therapy delivery vehicles due to their versatility, durability, and safety profile. Here we demonstrate extensive chimerism, manifesting as pervasive barcode swapping,...
8.
Hunker A, Mich J, Taskin N, Torkelson A, Pham T, Bertagnolli D, et al.
bioRxiv
. 2025 Jan;
PMID: 39868122
-acting regulatory enhancer elements are valuable tools for gaining cell type-specific genetic access. Leveraging large chromatin accessibility atlases, putative enhancer sequences can be identified and deployed in adeno-associated virus (AAV)...
9.
Agarwal V, Inoue F, Schubach M, Penzar D, Martin B, Dash P, et al.
Nature
. 2025 Jan;
639(8054):411-420.
PMID: 39814889
The human genome contains millions of candidate cis-regulatory elements (cCREs) with cell-type-specific activities that shape both health and many disease states. However, we lack a functional understanding of the sequence...
10.
Casto A, Paredes M, Bennett J, Luiten K, Han P, Gamboa L, et al.
Clin Chem
. 2025 Jan;
71(1):192-202.
PMID: 39749508
Background: Institutions of higher education (IHE) have been a focus of SARS-CoV-2 transmission studies but there is limited information on how viral diversity and transmission at IHE changed as the...