Brendan L OConnell
Overview
Explore the profile of Brendan L OConnell including associated specialties, affiliations and a list of published articles.
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17
Citations
766
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Recent Articles
1.
Nichols R, Rylaarsdam L, OConnell B, Shipony Z, Iremadze N, Acharya S, et al.
Cell Genom
. 2024 Dec;
5(1):100726.
PMID: 39719707
Single-cell methods to assess DNA methylation have not achieved the same level of cell throughput per experiment compared to other modalities, with large-scale datasets requiring extensive automation, time, and other...
2.
Rylaarsdam L, Nichols R, OConnell B, Coleman S, Yardimci G, Adey A
bioRxiv
. 2024 Aug;
PMID: 39211069
Single-cell sequencing technologies have revolutionized biomedical research by enabling deconvolution of cell type-specific properties in highly heterogeneous tissue. While robust tools have been developed to handle bioinformatic challenges posed by...
3.
Felton A, Spitzer R, Raubenheimer D, Hedwall P, Felton A, Nichols R, et al.
Ecology
. 2024 Jul;
105(9):e4377.
PMID: 39046431
Animals representing a wide range of taxonomic groups are known to select specific food combinations to achieve a nutritionally balanced diet. The nutrient balancing hypothesis suggests that, when given the...
4.
Acharya S, Nichols R, Rylaarsdam L, OConnell B, Braun T, Adey A
Genome Biol
. 2024 Jul;
25(1):186.
PMID: 38987810
DNA methylation is a key component of the mammalian epigenome, playing a regulatory role in development, disease, and other processes. Robust, high-throughput single-cell DNA methylation assays are now possible (sciMET);...
5.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2024 Mar;
187(5):1312-1313.
PMID: 38428398
No abstract available.
6.
Queitsch K, Moore T, OConnell B, Nichols R, Muschler J, Keith D, et al.
Cell Rep Methods
. 2023 Nov;
3(11):100625.
PMID: 37918402
Single-cell whole-genome sequencing (scWGS) enables the assessment of genome-level molecular differences between individual cells with particular relevance to genetically diverse systems like solid tumors. The application of scWGS was limited...
7.
Acharya S, Nichols R, Rylaarsdam L, OConnell B, Braun T, Adey A
bioRxiv
. 2023 Jul;
PMID: 37502923
DNA methylation is a key component of the mammalian epigenome, playing a regulatory role in development, disease, and other processes. Robust, high-throughput single-cell DNA methylation assays are now possible (sciMET);...
8.
OConnell B, Nichols R, Pokholok D, Thomas J, Acharya S, Nishida A, et al.
Genome Res
. 2023 Feb;
33(2):208-217.
PMID: 36792372
Here we present advancements in single-cell combinatorial indexed Assay for Transposase Accessible Chromatin (sciATAC) to measure chromatin accessibility that leverage nanowell chips to achieve atlas-scale cell throughput (>10 cells) at...
9.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2023 Jan;
186(2):305-326.e27.
PMID: 36638792
All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of...
10.
Nichols R, OConnell B, Mulqueen R, Thomas J, Woodfin A, Acharya S, et al.
Nat Commun
. 2022 Dec;
13(1):7627.
PMID: 36494343
DNA methylation is a key epigenetic property that drives gene regulatory programs in development and disease. Current single-cell methods that produce high quality methylomes are expensive and low throughput without...