Brian J ORoak
Overview
Explore the profile of Brian J ORoak including associated specialties, affiliations and a list of published articles.
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57
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13492
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Recent Articles
1.
Co M, OBrien G, Wright K, ORoak B
Autism Res
. 2024 Nov;
PMID: 39548698
Cre recombinase knock-in mouse lines have served as invaluable genetic tools for understanding key developmental processes altered in autism. However, insertion of exogenous DNA into the genome can have unintended...
2.
Co M, OBrien G, Wright K, ORoak B
bioRxiv
. 2024 Apr;
PMID: 38617321
Spatiotemporal control of Cre-mediated recombination has been an invaluable tool for understanding key developmental processes. For example, knock-in of into cell type marker gene loci drives expression under endogenous promoter...
3.
Streblow D, Hirsch A, Stanton J, Lewis A, Colgin L, Hessell A, et al.
Nat Commun
. 2023 Nov;
14(1):7062.
PMID: 37923717
Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent or blunt disease. Here, we examine the efficacy of aerosol mAb delivery to prevent infection and disease...
4.
OBrien T, Potter A, Driscoll C, Goh G, Letaw J, McCabe S, et al.
Am J Hum Genet
. 2023 Jul;
110(8):1249-1265.
PMID: 37506692
The Healthy Oregon Project (HOP) is a statewide effort that aims to build a large research repository and influence the health of Oregonians through providing no-cost genetic screening to participants...
5.
Zhou X, Feliciano P, Shu C, Wang T, Astrovskaya I, Hall J, et al.
Nat Genet
. 2022 Aug;
54(9):1305-1319.
PMID: 35982159
To capture the full spectrum of genetic risk for autism, we performed a two-stage analysis of rare de novo and inherited coding variants in 42,607 autism cases, including 35,130 new...
6.
Co M, Barnard R, Jahncke J, Grindstaff S, Fedorov L, Adey A, et al.
J Neurosci
. 2022 Aug;
42(37):7166-7181.
PMID: 35944998
T-Box Brain Transcription Factor 1 (TBR1) plays essential roles in brain development, mediating neuronal migration, fate specification, and axon tract formation. While heterozygous loss-of-function and missense mutations are associated with...
7.
Mighell T, Nishida A, OConnell B, Miller C, Grindstaff S, Thornton C, et al.
CRISPR J
. 2022 Jul;
5(4):548-557.
PMID: 35833801
Targeted sequencing remains a valuable technique for clinical and research applications. However, many existing technologies suffer from pervasive guanine-cytosine (GC) sequence content bias, high input DNA requirements, and high cost...
8.
Bates T, Leier H, Lyski Z, McBride S, Coulter F, Weinstein J, et al.
Nat Commun
. 2021 Aug;
12(1):5135.
PMID: 34446720
SARS-CoV-2 and its variants continue to infect hundreds of thousands every day despite the rollout of effective vaccines. Therefore, it is essential to understand the levels of protection that these...
9.
Fombonne E, Coppola L, Mastel S, ORoak B
J Autism Dev Disord
. 2021 Jul;
52(8):3383-3398.
PMID: 34328611
The SPARK cohort was established to facilitate recruitment in studies of large numbers of participants with autism spectrum disorder (ASD). Online registration requires participants to have received a lifetime professional...
10.
Mulqueen R, Pokholok D, OConnell B, Thornton C, Zhang F, ORoak B, et al.
Nat Biotechnol
. 2021 Jul;
39(12):1574-1580.
PMID: 34226710
Single-cell combinatorial indexing (sci) with transposase-based library construction increases the throughput of single-cell genomics assays but produces sparse coverage in terms of usable reads per cell. We develop symmetrical strand...