Amy E Mercer
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Explore the profile of Amy E Mercer including associated specialties, affiliations and a list of published articles.
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13
Citations
261
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Recent Articles
1.
ONeill P, Amewu R, Charman S, Sabbani S, Gnadig N, Straimer J, et al.
Nat Commun
. 2017 May;
8:15159.
PMID: 28537265
K13 gene mutations are a primary marker of artemisinin resistance in Plasmodium falciparum malaria that threatens the long-term clinical utility of artemisinin-based combination therapies, the cornerstone of modern day malaria...
2.
Copple I, Mercer A, Firman J, Donegan G, Herpers B, Wong M, et al.
Mol Med
. 2012 Jun;
18:1045-55.
PMID: 22669474
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites....
3.
Mercer A, Sarr Sallah M
Expert Opin Drug Metab Toxicol
. 2011 Feb;
7(4):427-39.
PMID: 21320023
Introduction: The use of artemisinin combination therapies to treat uncomplicated malaria is growing and, therefore, so is the number of children exposed to these agents. As a result, there is...
4.
Mercer A, Copple I, Maggs J, ONeill P, Park B
J Biol Chem
. 2010 Nov;
286(2):987-96.
PMID: 21059641
The artemisinin compounds are the frontline drugs for the treatment of drug-resistant malaria. They are selectively cytotoxic to mammalian cancer cell lines and have been implicated as neurotoxic and embryotoxic...
5.
Amewu R, Gibbons P, Mukhtar A, Stachulski A, Ward S, Hall C, et al.
Org Biomol Chem
. 2010 Apr;
8(9):2068-77.
PMID: 20401383
Thiol-Olefin Co-Oxygenation (TOCO) methodology has been applied to the synthesis of a small library of weak base and polar 1,2,4-trioxanes. The 1,2,4-trioxane units synthesised exhibit remarkable stability as they survive...
6.
Chadwick J, Jones M, Mercer A, Stocks P, Ward S, Park B, et al.
Bioorg Med Chem
. 2010 Mar;
18(7):2586-97.
PMID: 20227283
A series of artemisinin-spermidine conjugates designed to utilise the upregulated polyamine transporter found in cancer cells have been prepared. These conjugates were evaluated against human promyelocytic leukaemia HL-60 cells and...
7.
Mercer A, Regan S, Hirst C, Graham E, Antoine D, Benson C, et al.
Toxicol Appl Pharmacol
. 2009 Jun;
239(3):297-305.
PMID: 19523481
Unlabelled: Methapyrilene, [N,N-dimethyl-N'-pyridyl-N'(2-thienylmethyl)-1,2-ethanediamine] (MP) was withdrawn from, clinical use due to reported periportal hepatic necrosis and hepatocarcinogenicity in the rat, via S-oxidation of the thiophene group. In this study MP...
8.
Jones M, Mercer A, Stocks P, La Pensee L, Cosstick R, Park B, et al.
Bioorg Med Chem Lett
. 2009 Mar;
19(7):2033-7.
PMID: 19249201
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2-4-fold increase in activity...
9.
Mercer A
Curr Opin Drug Discov Devel
. 2009 Jan;
12(1):125-32.
PMID: 19152221
Artemisinin and artemisinin-based antimalarials are currently recommended as the frontline antimalarial treatment, with over 100 million courses administered annually. Despite possessing excellent therapeutic activity and tolerability, neurotoxicity and embryotoxicity have...
10.
Chadwick J, Mercer A, Park B, Cosstick R, ONeill P
Bioorg Med Chem
. 2009 Jan;
17(3):1325-38.
PMID: 19136263
A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity (as low as 30 pM) versus Plasmodium...