Richard Amewu
Overview
Explore the profile of Richard Amewu including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
223
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Osei-Safo D, Dziwornu G, Appiah-Opong R, Chama M, Tuffour I, Waibel R, et al.
Molecules
. 2017 Mar;
22(4).
PMID: 28346380
As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, , led to the isolation of the newly...
2.
Hong W, Gibbons P, Leung S, Amewu R, Stocks P, Stachulski A, et al.
J Med Chem
. 2017 Mar;
60(9):3703-3726.
PMID: 28304162
A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the...
3.
Miranda D, Capela R, Albuquerque I, Meireles P, Paiva I, Nogueira F, et al.
ACS Med Chem Lett
. 2014 Jun;
5(2):108-12.
PMID: 24900781
In a search for effective compounds against both the blood- and liver-stages of infection by malaria parasites with the ability to block the transmission of the disease to mosquito vectors,...
4.
Antoine T, Fisher N, Amewu R, ONeill P, Ward S, Biagini G
J Antimicrob Chemother
. 2013 Dec;
69(4):1005-16.
PMID: 24335485
Objectives: Artemisinin and artemisinin semi-synthetic derivatives (collectively known as endoperoxides) are first-line antimalarials for the treatment of uncomplicated and severe malaria. Endoperoxides display very fast killing rates and are generally...
5.
Leung S, Gibbons P, Amewu R, Nixon G, Pidathala C, Hong W, et al.
J Med Chem
. 2012 Feb;
55(5):1844-57.
PMID: 22364417
Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of...
6.
Pidathala C, Amewu R, Pacorel B, Nixon G, Gibbons P, Hong W, et al.
J Med Chem
. 2012 Feb;
55(5):1831-43.
PMID: 22364416
A program was undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a dehydrogenase of the mitochondrial electron transport chain of the malaria parasite Plasmodium falciparum. PfNDH2 has only one...
7.
Amewu R, Gibbons P, Mukhtar A, Stachulski A, Ward S, Hall C, et al.
Org Biomol Chem
. 2010 Apr;
8(9):2068-77.
PMID: 20401383
Thiol-Olefin Co-Oxygenation (TOCO) methodology has been applied to the synthesis of a small library of weak base and polar 1,2,4-trioxanes. The 1,2,4-trioxane units synthesised exhibit remarkable stability as they survive...
8.
Ellis G, Amewu R, Sabbani S, Stocks P, Shone A, Stanford D, et al.
J Med Chem
. 2008 Mar;
51(7):2170-7.
PMID: 18341274
A rapid, two-step synthesis of a range of dispiro-1,2,4,5-tetraoxanes with potent antimalarial activity both in vitro and in vivo has been achieved. These 1,2,4,5-tetraoxanes have been proven to be superior...
9.
Ellis G, Amewu R, Hall C, Rimmer K, Ward S, ONeill P
Bioorg Med Chem Lett
. 2008 Feb;
18(5):1720-4.
PMID: 18243702
Here we present an efficient route into synthetically challenging bridged 1,2,4,5-tetraoxanes. The key to the success of this route is the use of H(2)O(2) and catalytic I(2) to form the...
10.
Stocks P, Bray P, Barton V, Al-Helal M, Jones M, Araujo N, et al.
Angew Chem Int Ed Engl
. 2007 Jul;
46(33):6278-83.
PMID: 17640025
No abstract available.