Stephen A Ward
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Explore the profile of Stephen A Ward including associated specialties, affiliations and a list of published articles.
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Articles
162
Citations
3339
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Recent Articles
1.
Quek S, Hadermann A, Wu Y, De Coninck L, Hegde S, Boucher J, et al.
Nat Microbiol
. 2024 Sep;
9(10):2488-2505.
PMID: 39232205
Parasitic nematodes have an intimate, chronic and lifelong exposure to vertebrate tissues. Here we mined 41 published parasitic nematode transcriptomes from vertebrate hosts and identified 91 RNA viruses across 13...
2.
Devereux G, Bula M, Tripp K, FitzGerald R, Eraut N, Alam M, et al.
Clin Pharmacol Drug Dev
. 2024 Jun;
13(9):1071-1081.
PMID: 38924387
AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This...
3.
Lisauskaite M, Nixon G, Woodley C, Berry N, Coninckx A, Qie L, et al.
RSC Chem Biol
. 2024 Jan;
5(1):19-29.
PMID: 38179191
The emergence of parasite resistance to current front-line antimalarial treatments poses a serious threat to global malaria control and highlights the necessity for the development of therapeutics with novel targets...
4.
Jeffreys L, Ardrey A, Hafiz T, Dyer L, Warman A, Mosallam N, et al.
ACS Infect Dis
. 2023 Jan;
9(2):221-238.
PMID: 36606559
cytochrome quinol oxidase (cyt ), the alternative terminal oxidase of the respiratory chain, has been identified as playing a key role during chronic infection and presents a putative target for...
5.
Amporndanai K, Pinthong N, ONeill P, Hong W, Amewu R, Pidathala C, et al.
Biology (Basel)
. 2022 Jul;
11(8).
PMID: 35892964
Antimalarials targeting the ubiquinol-oxidation (Q) site of the bc complex, such as atovaquone, have become less effective due to the rapid emergence of resistance linked to point mutations in the...
6.
Quek S, Cook D, Wu Y, Marriott A, Steven A, Johnston K, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(15):e2120003119.
PMID: 35377795
Lymphatic filariasis is a vector-borne neglected tropical disease prioritized for global elimination. The filarial nematodes that cause the disease host a symbiotic bacterium, Wolbachia, which has been targeted using antibiotics,...
7.
Jeffreys L, Pennington S, Duggan J, Caygill C, Lopeman R, Breen A, et al.
Int J Antimicrob Agents
. 2022 Jan;
59(3):106542.
PMID: 35093538
A key element for the prevention and management of coronavirus disease 2019 is the development of effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have the potential...
8.
McGillan P, Berry N, Nixon G, Leung S, Webborn P, Wenlock M, et al.
ACS Med Chem Lett
. 2021 Sep;
12(9):1421-1426.
PMID: 34527179
Anti- therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti- activity. This paper focuses on the...
9.
Woodley C, Nixon G, Basilico N, Parapini S, Hong W, Ward S, et al.
ACS Med Chem Lett
. 2021 Jul;
12(7):1077-1085.
PMID: 34267877
Synthetic endoperoxide antimalarials, such as 1,2,4-trioxolanes and 1,2,4,5-tetraoxanes, are promising successors for current front-line antimalarials, semisynthetic artemisinin derivatives. However, limited solubility of second-generation analogues in biological-relevant media represents a barrier...
10.
Johnston K, Hong W, Turner J, ONeill P, Ward S, Taylor M
Trends Parasitol
. 2021 Jul;
37(12):1068-1081.
PMID: 34229954
The mutualistic association between Wolbachia endosymbionts and their filarial nematode hosts has been exploited as a validated drug target delivering macrofilaricidal outcomes. Limitations of existing antibiotics to scale-up have driven...