Michael S Bonkowski
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Explore the profile of Michael S Bonkowski including associated specialties, affiliations and a list of published articles.
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36
Citations
2267
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Recent Articles
1.
Kane A, Chellappa K, Schultz M, Arnold M, Li J, Amorim J, et al.
bioRxiv
. 2024 Jul;
PMID: 38979132
Nicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those involved in energy metabolism, DNA repair and the activity of sirtuins, a family of defensive deacylases. During aging,...
2.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2024 Mar;
187(5):1312-1313.
PMID: 38428398
No abstract available.
3.
Yang J, Hayano M, Griffin P, Amorim J, Bonkowski M, Apostolides J, et al.
Cell
. 2023 Jan;
186(2):305-326.e27.
PMID: 36638792
All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of...
4.
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, et al.
Nature
. 2020 Dec;
588(7836):124-129.
PMID: 33268865
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, leading to...
5.
Schultz M, Kane A, Mitchell S, MacArthur M, Warner E, Vogel D, et al.
Nat Commun
. 2020 Oct;
11(1):5143.
PMID: 33033247
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
6.
Schultz M, Kane A, Mitchell S, MacArthur M, Warner E, Vogel D, et al.
Nat Commun
. 2020 Sep;
11(1):4618.
PMID: 32934233
The identification of genes and interventions that slow or reverse aging is hampered by the lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty Indices...
7.
Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al.
Cell
. 2019 Feb;
176(4):944-945.
PMID: 30735637
No abstract available.
8.
Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al.
Cell
. 2018 Mar;
173(1):74-89.e20.
PMID: 29570999
A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health....
9.
Li J, Bonkowski M, Moniot S, Zhang D, Hubbard B, Ling A, et al.
Science
. 2017 Mar;
355(6331):1312-1317.
PMID: 28336669
DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We...
10.
Pollack R, Barzilai N, Anghel V, Kulkarni A, Golden A, OBroin P, et al.
J Gerontol A Biol Sci Med Sci
. 2017 Mar;
72(12):1703-1709.
PMID: 28329397
Background: Resveratrol, a plant-derived polyphenol, has been reported to improve glucose metabolism and vascular function and to extend life span in animal models, but studies in humans have been inconclusive....