Alexandre Chigaev
Overview
Explore the profile of Alexandre Chigaev including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
952
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Recent Articles
1.
Matthijssens F, Sharma N, Nysus M, Nickl C, Kang H, Perez D, et al.
J Clin Invest
. 2021 Feb;
131(6).
PMID: 33555272
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2)...
2.
Gutjahr J, Bayer E, Yu X, Laufer J, Hopner J, Tesanovic S, et al.
Haematologica
. 2020 Jul;
106(8):2102-2113.
PMID: 32616529
Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell...
3.
Szenes E, Harzschel A, Decker S, Tissino E, Pischeli J, Gutjahr J, et al.
Leukemia
. 2020 Feb;
34(9):2498-2502.
PMID: 32086446
No abstract available.
4.
Perez D, Sklar L, Chigaev A, Matlawska-Wasowska K
Semin Cancer Biol
. 2020 Feb;
68:199-208.
PMID: 32044470
While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation...
5.
Perez D, Sklar L, Chigaev A
Pharmacol Ther
. 2019 Mar;
199:155-163.
PMID: 30898518
Clioquinol, one of the first mass-produced drugs, was considered safe and efficacious for many years. It was used as an antifungal and an antiprotozoal drug until it was linked to...
6.
Sambrano J, Chigaev A, Nichani K, Smagley Y, Sklar L, Houston J
J Biomed Opt
. 2018 Jul;
23(7):1-10.
PMID: 29992797
Förster resonance energy transfer (FRET) continues to be a useful tool to study movement and interaction between proteins within living cells. When FRET as an optical technique is measured with...
7.
Perez D, Edwards B, Sklar L, Chigaev A
SLAS Discov
. 2018 May;
23(7):751-760.
PMID: 29842834
Classical therapeutic regimens are subject to toxicity, low efficacy, and/or the development of drug resistance. Thus, the discovery of synergistic drug combinations would permit treatment with lower, tolerable dosages of...
8.
Perez D, Nickl C, Waller A, Delgado-Martin C, Woods T, Sharma N, et al.
SLAS Discov
. 2018 May;
23(7):732-741.
PMID: 29746793
Kinase inhibitors have dramatically increased patient survival in a multitude of cancers, including hematological malignancies. However, kinase inhibitors have not yet been integrated into current clinical trials for patients with...
9.
Tissino E, Benedetti D, Herman S, Ten Hacken E, Ahn I, Chaffee K, et al.
J Exp Med
. 2018 Jan;
215(2):681-697.
PMID: 29301866
The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, which antagonizes B cell receptor (BCR) signals, demonstrates remarkable clinical activity in chronic lymphocytic leukemia (CLL). The lymphocytosis experienced by most patients under...
10.
Zucchetto A, Tissino E, Hartmann T, Chigaev A, Del Poeta G, Colombatti A, et al.
Clin Cancer Res
. 2016 Jul;
22(13):3410-1.
PMID: 27371631
No abstract available.