Alexander Golks
Overview
Explore the profile of Alexander Golks including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
838
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Recent Articles
1.
Lavrik I, Mock T, Golks A, Hoffmann J, Baumann S, Krammer P
J Biol Chem
. 2008 Jul;
283(39):26401-8.
PMID: 18635548
Stimulation of CD95 (APO-1/Fas) by its natural ligand CD95L (APO-1L/FasL) leads to the formation of the death-inducing signaling complex. Here we report that upon CD95 stimulation in several T and...
2.
Golks A, Guerini D
EMBO Rep
. 2008 Jul;
9(8):748-53.
PMID: 18617890
The intracellular modification of proteins by the addition of a single O-linked N-acetylglucosamine (O-GlcNAc) molecule is a ubiquitous post-translational modification in eukaryotic cells. It is catalysed by O-linked N-acetylglucosaminyltransferase, which...
3.
Golks A, Tran T, Goetschy J, Guerini D
EMBO J
. 2007 Sep;
26(20):4368-79.
PMID: 17882263
The dynamic modification of nuclear and cytoplasmic proteins with O-linked beta-N-acetylglucosamine (O-GlcNAc) by the O-linked N-acetylglucosaminyltransferase (OGT) is a regulatory post-translational modification that is responsive to various stimuli. Here, we...
4.
Brenner D, Golks A, Becker M, Muller W, Frey C, Novak R, et al.
Blood
. 2007 Aug;
110(12):3968-77.
PMID: 17712048
Life and death of peripheral lymphocytes is strictly controlled to maintain physiologic levels of T and B cells. Activation-induced cell death (AICD) is one mechanism to delete superfluous lymphocytes by...
5.
Lavrik I, Golks A, Riess D, Bentele M, Eils R, Krammer P
J Biol Chem
. 2007 Mar;
282(18):13664-71.
PMID: 17347143
Recently we generated a mathematical model (Bentele, M., Lavrik, I., Ulrich, M., Stosser, S., Heermann, D. W., Kalthoff, H., Krammer, P. H., and Eils, R. (2004) J. Cell Biol. 166,...
6.
Lavrik I, Golks A, Baumann S, Krammer P
Blood
. 2006 Jul;
108(2):559-65.
PMID: 16822901
Caspase-2 was reported to be involved in a number of apoptotic pathways triggered by various stimuli. However, the molecular mechanism of procaspase-2 activation in the course of apoptosis remains poorly...
7.
Golks A, Brenner D, Krammer P, Lavrik I
J Exp Med
. 2006 May;
203(5):1295-305.
PMID: 16682493
c-FLIP proteins (isoforms: c-FLIP(L), c-FLIP(S), and c-FLIP(R)) play an essential role in the regulation of death receptor-induced apoptosis. Here, we demonstrate that the cytoplasmic NH2-terminal procaspase-8 cleavage product of c-FLIP...
8.
Brenner D, Golks A, Kiefer F, Krammer P, Arnold R
EMBO J
. 2005 Dec;
24(24):4279-90.
PMID: 16341093
Restimulation of the T-cell receptor (TCR) in activated T cells induces CD95 (Fas/Apo-1)-mediated activation-induced cell death (AICD). The TCR-proximal mechanisms leading to AICD are elusive. Here we characterize hematopoietic progenitor...
9.
Lavrik I, Golks A, Krammer P
J Clin Invest
. 2005 Oct;
115(10):2665-72.
PMID: 16200200
Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made to further understand caspase structure and function, providing a...
10.
Golks A, Brenner D, Fritsch C, Krammer P, Lavrik I
J Biol Chem
. 2005 Feb;
280(15):14507-13.
PMID: 15701649
c-FLIPs (c-FLICE inhibitory proteins) play an essential role in regulation of death receptor-induced apoptosis. Multiple splice variants of c-FLIP have been described on the mRNA level; so far only two...