Rudiger Arnold
Overview
Explore the profile of Rudiger Arnold including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
754
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Recent Articles
1.
Benhamou D, Labi V, Novak R, Dai I, Shafir-Alon S, Weiss A, et al.
Cell Rep
. 2016 Jun;
16(2):419-431.
PMID: 27346348
PI3K activity determines positive and negative selection of B cells, a key process for immune tolerance and B cell maturation. Activation of PI3K is balanced by phosphatase and tensin homolog...
2.
Breuer R, Becker M, Brechmann M, Mock T, Arnold R, Krammer P
J Biol Chem
. 2014 Apr;
289(21):14996-5004.
PMID: 24719332
NF-κB is an important transcription factor in the immune system, and aberrant NF-κB activity contributes to malignant diseases and autoimmunity. In T cells, NF-κB is activated upon TCR stimulation, and...
3.
Brechmann M, Mock T, Nickles D, Kiessling M, Weit N, Breuer R, et al.
Immunity
. 2012 Oct;
37(4):697-708.
PMID: 23084358
Signal transduction to nuclear factor-kappa B (NF-κB) involves multiple kinases and phosphorylated target proteins, but little is known about signal termination by dephosphorylation. By RNAi screening, we have identified protein...
4.
Brenner D, Brechmann M, Rohling S, Tapernoux M, Mock T, Winter D, et al.
Proc Natl Acad Sci U S A
. 2009 Aug;
106(34):14508-13.
PMID: 19706536
Activation of the NF-kappaB pathway in T cells is required for induction of an adaptive immune response. Hematopoietic progenitor kinase (HPK1) is an important proximal mediator of T-cell receptor (TCR)-induced...
5.
Brenner D, Krammer P, Arnold R
Crit Rev Oncol Hematol
. 2008 Feb;
66(1):52-64.
PMID: 18289867
Lymphocytes of the adaptive immune system play a crucial role in defending the organism against pathogens. Initial stimulation via antigen receptors induces activation and proliferation of lymphocytes to generate effector...
6.
Brenner D, Golks A, Becker M, Muller W, Frey C, Novak R, et al.
Blood
. 2007 Aug;
110(12):3968-77.
PMID: 17712048
Life and death of peripheral lymphocytes is strictly controlled to maintain physiologic levels of T and B cells. Activation-induced cell death (AICD) is one mechanism to delete superfluous lymphocytes by...
7.
Krammer P, Arnold R, Lavrik I
Nat Rev Immunol
. 2007 Jun;
7(7):532-42.
PMID: 17589543
During the course of an immune response, antigen-reactive T cells clonally expand and then are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is determined...
8.
Fassbinder E, Rudolf S, Bussiek A, Kroger C, Arnold R, Greggersen W, et al.
Psychother Psychosom Med Psychol
. 2007 Apr;
57(3-4):161-9.
PMID: 17427099
Background: The beneficial effects of Dialectical Behavior Therapy (DBT) for patients with borderline personality disorder (BPD) are well established. However, it is not well known whether this type of treatment...
9.
Graichen F, Arnold R, Rohlmann A, Bergmann G
IEEE Trans Biomed Eng
. 2007 Feb;
54(2):253-61.
PMID: 17278582
Knowledge of the loads to which orthopedic implants are subjected is a fundamental prerequisite for their optimal biomechanical design, long-term success, and improved rehabilitation outcomes. In vivo load measurements are...
10.
Arnold R, Brenner D, Becker M, Frey C, Krammer P
Eur J Immunol
. 2006 Jun;
36(7):1654-8.
PMID: 16791883
While insufficient cell death of activated T cells can result in autoimmune disorders, elimination of too many T cells can lead to immunodeficiency. Therefore, T lymphocyte fate is highly regulated...