Danilo Guerini
Overview
Explore the profile of Danilo Guerini including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1541
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Recent Articles
1.
Greiner-Tollersrud O, Krausz M, Boehler V, Polyzou A, Seidl M, Spahiu A, et al.
Cell Rep
. 2024 Oct;
43(11):114899.
PMID: 39441717
Although adenosine deaminase 2 (ADA2) is considered an extracellular ADA, evidence questions the physiological relevance of this activity. Our study reveals that ADA2 localizes within the lysosomes, where it is...
2.
Mutlu M, Schmidt I, Morrison A, Goretzki B, Freuler F, Begue D, et al.
Nat Commun
. 2024 May;
15(1):4584.
PMID: 38811577
Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its...
3.
Guerini D
Cells
. 2022 Apr;
11(7).
PMID: 35406723
The cGAS STING pathway has received much attention in recent years, and it has been recognized as an important component of the innate immune response. Since the discovery of STING...
4.
Morozzi G, Rothen J, Toussaint G, De Lange K, Westritschnig K, Doelemeyer A, et al.
iScience
. 2021 Dec;
24(12):103434.
PMID: 34877494
Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI). PNI triggers inflammatory responses at the site of injury. The DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream...
5.
Willemsen J, Neuhoff M, Hoyler T, Noir E, Tessier C, Sarret S, et al.
Cell Rep
. 2021 Nov;
37(6):109977.
PMID: 34758308
Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues show an interferon-stimulated gene signature....
6.
Velcicky J, Mathison C, Nikulin V, Pflieger D, Epple R, Azimioara M, et al.
ACS Med Chem Lett
. 2019 Jun;
10(6):887-892.
PMID: 31223443
SPPL2a (Signal Peptide Peptidase Like 2a) is an intramembrane aspartyl protease engaged in the function of B-cells and dendritic cells. Despite being an attractive target for modulation of the immune...
7.
Velcicky J, Bodendorf U, Rigollier P, Epple R, Beisner D, Guerini D, et al.
J Med Chem
. 2018 Jan;
61(3):865-880.
PMID: 29359565
Signal peptide peptidase-like 2a (SPPL2a) is an aspartic intramembrane protease which has recently been shown to play an important role in the development and function of antigen presenting cells such...
8.
Rao V, Webster S, Dalm V, Sediva A, van Hagen P, Holland S, et al.
Blood
. 2017 Oct;
130(21):2307-2316.
PMID: 28972011
Pathogenic gain-of-function variants in the genes encoding phosphoinositide 3-kinase δ (PI3Kδ) lead to accumulation of transitional B cells and senescent T cells, lymphadenopathy, and immune deficiency (activated PI3Kδ syndrome [APDS])....
9.
Zhang X, Gotte M, Ibig-Rehm Y, Schuffenhauer A, Kamke M, Beisner D, et al.
SLAS Discov
. 2017 Jul;
22(9):1106-1119.
PMID: 28731783
The intramembrane protease signal peptide peptidase-like 2a (SPPL2a) is a potential drug target for the treatment of autoimmune diseases due to an essential role in B cells and dendritic cells....
10.
Sykes D, Riddy D, Stamp C, Bradley M, McGuiness N, Sattikar A, et al.
Br J Pharmacol
. 2014 Mar;
171(21):4797-807.
PMID: 24641481
Background And Purpose: The molecular mechanism underlying the clinical efficacy of FTY720-P is thought to involve persistent internalization and enhanced degradation of the S1P1 receptor subtype (S1P1R). We have investigated...