Dirk Brenner
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Explore the profile of Dirk Brenner including associated specialties, affiliations and a list of published articles.
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75
Citations
4602
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Recent Articles
1.
Harm J, Fan Y, Brenner D
Curr Opin Immunol
. 2024 Dec;
92():102511.
PMID: 39674060
Regulatory T cells (Tregs) are essential for maintaining immune homeostasis, playing crucial roles in modulating autoimmune conditions and contributing to the suppressive tumor microenvironment. Their cellular metabolism governs their generation,...
2.
Pogorelov D, Bode S, He X, Ramiro-Garcia J, Hedin F, Ammerlaan W, et al.
Nat Commun
. 2024 Nov;
15(1):10266.
PMID: 39592626
Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest success rate (>95%) for insect venom while a much lower chance for pollen allergy. However, the molecular switches leading to successful...
3.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
Nat Commun
. 2024 Jul;
15(1):6152.
PMID: 39034312
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
4.
Bonetti L, Horkova V, Grusdat M, Longworth J, Guerra L, Kurniawan H, et al.
Cell Metab
. 2024 Jul;
36(8):1726-1744.e10.
PMID: 38986617
The intestinal tract generates significant reactive oxygen species (ROS), but the role of T cell antioxidant mechanisms in maintaining intestinal homeostasis is poorly understood. We used T cell-specific ablation of...
5.
6.
Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, et al.
Nat Cancer
. 2023 Sep;
4(10):1508-1525.
PMID: 37723306
The PDCD1-encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). The highest frequencies of PDCD1 deletions...
7.
Bonetti L, Horkova V, Longworth J, Guerra L, Kurniawan H, Franchina D, et al.
bioRxiv
. 2023 Jul;
PMID: 37489135
Although the intestinal tract is a major site of reactive oxygen species (ROS) generation, the mechanisms by which antioxidant defense in gut T cells contribute to intestinal homeostasis are currently...
8.
Cable J, Rathmell J, Pearce E, Ho P, Haigis M, Mamedov M, et al.
Ann N Y Acad Sci
. 2023 Mar;
1523(1):38-50.
PMID: 36960914
Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on...
9.
Soriano-Baguet L, Grusdat M, Kurniawan H, Benzarti M, Binsfeld C, Ewen A, et al.
Cell Rep
. 2023 Feb;
42(3):112153.
PMID: 36848289
Pyruvate dehydrogenase (PDH) is the central enzyme connecting glycolysis and the tricarboxylic acid (TCA) cycle. The importance of PDH function in T helper 17 (Th17) cells still remains to be...
10.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
bioRxiv
. 2023 Feb;
PMID: 36798186
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...