Alexander G Fletcher
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Explore the profile of Alexander G Fletcher including associated specialties, affiliations and a list of published articles.
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62
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1611
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Recent Articles
1.
Trinidad L, Fletcher A, Strutt D
Curr Biol
. 2024 Dec;
35(2):422-430.e3.
PMID: 39708794
During tissue morphogenesis, an interplay of biochemical pathways and mechanical cues regulates polarized cell behaviors, the balance of which leads to tissues reaching their correct shape and size. A well-studied...
2.
Cammarota C, Dawney N, Bellomio P, Jung M, Fletcher A, Finegan T, et al.
PLoS Comput Biol
. 2024 Apr;
20(4):e1012001.
PMID: 38557605
Epithelial tissues are the most abundant tissue type in animals, lining body cavities and generating compartment barriers. The function of a monolayered epithelial tissue-whether protective, secretory, absorptive, or filtrative-relies on...
3.
Groves I, Holmshaw J, Furley D, Manning E, Chinnaiya K, Towers M, et al.
Development
. 2023 Oct;
150(22).
PMID: 37830145
Recent work shows that the developmental potential of progenitor cells in the HH10 chick brain changes rapidly, accompanied by subtle changes in morphology. This demands increased temporal resolution for studies...
4.
Strawbridge S, Kurowski A, Corujo-Simon E, Fletcher A, Nichols J, Fletcher A
Biol Open
. 2023 Aug;
12(9).
PMID: 37623821
A crucial aspect of embryology is relating the position of individual cells to the broader geometry of the embryo. A classic example of this is the first cell-fate decision of...
5.
Montes-Olivas S, Legge D, Lund A, Fletcher A, Williams A, Marucci L, et al.
PLoS Comput Biol
. 2023 Aug;
19(8):e1011386.
PMID: 37578984
Organoids offer a powerful model to study cellular self-organisation, the growth of specific tissue morphologies in-vitro, and to assess potential medical therapies. However, the intrinsic mechanisms of these systems are...
6.
Cammarota C, Dawney N, Bellomio P, Jung M, Fletcher A, Finegan T, et al.
bioRxiv
. 2023 May;
PMID: 37214914
Epithelial tissues are the most abundant tissue type in animals, lining body cavities and generating compartment barriers. The function of a monolayer epithelium - whether protective, secretory, absorptive, or filtrative...
7.
Cooper F, Baker R, Bernabeu M, Bordas R, Bowler L, Bueno-Orovio A, et al.
J Open Source Softw
. 2023 May;
5(47):1848.
PMID: 37192932
Chaste (Cancer, Heart And Soft Tissue Environment) is an open source simulation package for the numerical solution of mathematical models arising in physiology and biology. To date, Chaste development has...
8.
Schmidt A, Finegan T, Haring M, Kong D, Fletcher A, Alam Z, et al.
Mol Biol Cell
. 2023 May;
34(8):ar81.
PMID: 37163320
During embryonic development, dramatic cell shape changes and movements reshape the embryonic body plan. These require robust but dynamic linkage between the cell-cell adherens junctions and the force-generating actomyosin cytoskeleton....
9.
Schmidt A, Finegan T, Haring M, Kong D, Fletcher A, Alam Z, et al.
bioRxiv
. 2023 Mar;
PMID: 36909597
During embryonic development dramatic cell shape changes and movements re-shape the embryonic body plan. These require robust but dynamic linkage between the cell-cell adherens junctions and the force-generating actomyosin cytoskeleton....
10.
Johnson C, Fletcher A, Soyer O
Gigascience
. 2022 Jun;
11.
PMID: 35715874
Background: Spatial organization plays an important role in the function of many biological systems, from cell fate specification in animal development to multistep metabolic conversions in microbial communities. The study...