Guy B Blanchard
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Explore the profile of Guy B Blanchard including associated specialties, affiliations and a list of published articles.
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28
Citations
1018
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Recent Articles
1.
Lye C, Blanchard G, Evans J, Nestor-Bergmann A, Sanson B
PLoS Biol
. 2024 Apr;
22(4):e3002611.
PMID: 38683880
As tissues grow and change shape during animal development, they physically pull and push on each other, and these mechanical interactions can be important for morphogenesis. During Drosophila gastrulation, mesoderm...
2.
Blanchard G, Scarpa E, Muresan L, Sanson B
Development
. 2024 Apr;
151(10).
PMID: 38639390
The planar orientation of cell division (OCD) is important for epithelial morphogenesis and homeostasis. Here, we ask how mechanics and antero-posterior (AP) patterning combine to influence the first divisions after...
3.
Sharrock T, Evans J, Blanchard G, Sanson B
Development
. 2022 Sep;
149(21).
PMID: 36178136
Compartmental boundaries physically separate developing tissues into distinct regions, which is fundamental for the organisation of the body plan in both insects and vertebrates. In many examples, this physical segregation...
4.
Fierling J, John A, Delorme B, Torzynski A, Blanchard G, Lye C, et al.
Nat Commun
. 2022 Jun;
13(1):3348.
PMID: 35688832
Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism during tissue folding in embryo development. While much is now understood of the molecular mechanism responsible for apical...
5.
Nestor-Bergmann A, Blanchard G, Hervieux N, Fletcher A, Etienne J, Sanson B
PLoS Comput Biol
. 2022 Jan;
18(1):e1009812.
PMID: 35089922
Cell intercalation is a key cell behaviour of morphogenesis and wound healing, where local cell neighbour exchanges can cause dramatic tissue deformations such as body axis extension. Substantial experimental work...
6.
Sanchez-Corrales Y, Blanchard G, Roper K
Elife
. 2021 Nov;
10.
PMID: 34723792
During organ development, tubular organs often form from flat epithelial primordia. In the placodes of the forming tubes of the salivary glands in the embryo, we previously identified spatially defined...
7.
Moreno L, Barone G, Dubois S, Molenaar J, Fischer M, Schulte J, et al.
Eur J Cancer
. 2020 Jul;
136:52-68.
PMID: 32653773
Only one class of targeted agents (anti-GD2 antibodies) has been incorporated into front-line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug Development Strategy (NDDS) initiative commenced in 2012...
8.
Finegan T, Hervieux N, Nestor-Bergmann A, Fletcher A, Blanchard G, Sanson B
PLoS Biol
. 2019 Dec;
17(12):e3000522.
PMID: 31805038
In epithelia, tricellular vertices are emerging as important sites for the regulation of epithelial integrity and function. Compared to bicellular contacts, however, much less is known. In particular, resident proteins...
9.
Scarpa E, Finet C, Blanchard G, Sanson B
Dev Cell
. 2018 Dec;
47(6):727-740.e6.
PMID: 30503752
Cell shape is known to influence the plane of cell division. In vitro, mechanical constraints can also orient mitoses; however, in vivo it is not clear whether tension can orient...
10.
Blanchard G, Etienne J, Gorfinkiel N
Curr Opin Genet Dev
. 2018 Aug;
51:78-87.
PMID: 30077073
We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator...