Jochen Kursawe
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Explore the profile of Jochen Kursawe including associated specialties, affiliations and a list of published articles.
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14
Citations
136
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Recent Articles
1.
De Carli A, Kapelyukh Y, Kursawe J, Chaplain M, Wolf C, Hamis S
NPJ Syst Biol Appl
. 2024 May;
10(1):51.
PMID: 38750040
In vertical inhibition treatment strategies, multiple components of an intracellular pathway are simultaneously inhibited. Vertical inhibition of the BRAFV600E-MEK-ERK signalling pathway is a standard of care for treating BRAFV600E-mutated melanoma...
2.
Mathias S, Adameyko I, Hellander A, Kursawe J
PLoS Comput Biol
. 2023 Nov;
19(11):e1011658.
PMID: 38019884
During early development, cartilage provides shape and stability to the embryo while serving as a precursor for the skeleton. Correct formation of embryonic cartilage is hence essential for healthy development....
3.
Cooper F, Baker R, Bernabeu M, Bordas R, Bowler L, Bueno-Orovio A, et al.
J Open Source Softw
. 2023 May;
5(47):1848.
PMID: 37192932
Chaste (Cancer, Heart And Soft Tissue Environment) is an open source simulation package for the numerical solution of mathematical models arising in physiology and biology. To date, Chaste development has...
4.
Soto X, Burton J, Manning C, Minchington T, Lea R, Lee J, et al.
Development
. 2022 Oct;
149(19).
PMID: 36189829
MicroRNAs (miRs) have an important role in tuning dynamic gene expression. However, the mechanism by which they are quantitatively controlled is unknown. We show that the amount of mature miR-9,...
5.
Sabherwal N, Rowntree A, Marinopoulou E, Pettini T, Hourihane S, Thomas R, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(45).
PMID: 34725165
Here, we study the dynamical expression of endogenously labeled Hes1, a transcriptional repressor implicated in controlling cell proliferation, to understand how cell-cycle length heterogeneity is generated in estrogen receptor (ER)...
6.
Burton J, Manning C, Rattray M, Papalopulu N, Kursawe J
J R Soc Interface
. 2021 Sep;
18(182):20210393.
PMID: 34583566
Gene expression dynamics, such as stochastic oscillations and aperiodic fluctuations, have been associated with cell fate changes in multiple contexts, including development and cancer. Single cell live imaging of protein...
7.
A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord
Biga V, Hawley J, Soto X, Johns E, Han D, Bennett H, et al.
Mol Syst Biol
. 2021 May;
17(5):e9902.
PMID: 34031978
Ultradian oscillations of HES Transcription Factors (TFs) at the single-cell level enable cell state transitions. However, the tissue-level organisation of HES5 dynamics in neurogenesis is unknown. Here, we analyse the...
8.
Ruske L, Kursawe J, Tsakiridis A, Wilson V, Fletcher A, Blythe R, et al.
Phys Biol
. 2020 Jun;
17(6):065009.
PMID: 32585646
The deluge of single-cell data obtained by sequencing, imaging and epigenetic markers has led to an increasingly detailed description of cell state. However, it remains challenging to identify how cells...
9.
Soto X, Biga V, Kursawe J, Lea R, Doostdar P, Thomas R, et al.
EMBO J
. 2020 May;
39(12):e103558.
PMID: 32395844
Noise is prevalent in biology and has been widely quantified using snapshot measurements. This static view obscures our understanding of dynamic noise properties and how these affect gene expression and...
10.
Manning C, Biga V, Boyd J, Kursawe J, Ymisson B, Spiller D, et al.
Nat Commun
. 2019 Jun;
10(1):2835.
PMID: 31249377
During embryogenesis cells make fate decisions within complex tissue environments. The levels and dynamics of transcription factor expression regulate these decisions. Here, we use single cell live imaging of an...