Aleksandrina Goeva
Overview
Explore the profile of Aleksandrina Goeva including associated specialties, affiliations and a list of published articles.
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8
Citations
2127
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Recent Articles
1.
Goeva A, Dolan M, Luu J, Garcia E, Boiarsky R, Gupta R, et al.
Nat Commun
. 2024 Nov;
15(1):9468.
PMID: 39487129
In case-control single-cell RNA-seq studies, sample-level labels are transferred onto individual cells, labeling all case cells as affected, when in reality only a small fraction of them may actually be...
2.
Yang A, Chidiac R, Russo E, Steenland H, Pauli Q, Bonin R, et al.
Development
. 2024 Feb;
151(5).
PMID: 38358799
The Wnt/β-catenin signaling governs anterior-posterior neural patterning during development. Current human pluripotent stem cell (hPSC) differentiation protocols use a GSK3 inhibitor to activate Wnt signaling to promote posterior neural fate...
3.
Dolan M, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, et al.
Nat Immunol
. 2023 Jul;
24(8):1382-1390.
PMID: 37500887
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes known as states. Understanding state function, especially...
4.
Adler M, Moriel N, Goeva A, Avraham-Davidi I, Mages S, Adams T, et al.
Cell Rep
. 2023 Apr;
42(5):112412.
PMID: 37086403
Most cell types in multicellular organisms can perform multiple functions. However, not all functions can be optimally performed simultaneously by the same cells. Functions incompatible at the level of individual...
5.
Cable D, Murray E, Zou L, Goeva A, Macosko E, Chen F, et al.
Nat Biotechnol
. 2021 Feb;
40(4):517-526.
PMID: 33603203
A limitation of spatial transcriptomics technologies is that individual measurements may contain contributions from multiple cells, hindering the discovery of cell-type-specific spatial patterns of localization and expression. Here, we develop...
6.
Rodriques S, Stickels R, Goeva A, Martin C, Murray E, Vanderburg C, et al.
Science
. 2019 Mar;
363(6434):1463-1467.
PMID: 30923225
Spatial positions of cells in tissues strongly influence function, yet a high-throughput, genome-wide readout of gene expression with cellular resolution is lacking. We developed Slide-seq, a method for transferring RNA...
7.
Saunders A, Macosko E, Wysoker A, Goldman M, Krienen F, de Rivera H, et al.
Cell
. 2018 Aug;
174(4):1015-1030.e16.
PMID: 30096299
The mammalian brain is composed of diverse, specialized cell populations. To systematically ascertain and learn from these cellular specializations, we used Drop-seq to profile RNA expression in 690,000 individual cells...
8.
Kramer J, Helfrich C, Levin M, Hwang I, Samuel P, Carrellas A, et al.
Dev Med Child Neurol
. 2018 Mar;
60(8):801-809.
PMID: 29528103
Aim: Project TEAM (Teens making Environment and Activity Modifications) teaches transition-age young people with developmental disabilities, including those with co-occurring intellectual or cognitive disabilities, to identify and resolve environmental barriers...