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Evan Z Macosko

Explore the profile of Evan Z Macosko including associated specialties, affiliations and a list of published articles. Areas
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Articles 65
Citations 11456
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Recent Articles
1.
Marsh S, Walker A, Kamath T, Dissing-Olesen L, Hammond T, de Soysa T, et al.
Nat Neurosci . 2024 Dec; 28(1):215. PMID: 39672966
No abstract available.
2.
Hochbaum D, Hulshof L, Urke A, Wang W, Dubinsky A, Farnsworth H, et al.
Cell . 2024 Aug; 187(20):5679-5697.e23. PMID: 39178853
Animals adapt to environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of...
3.
Wu S, Dai M, Yang S, McCann C, Qiu Y, Marrero G, et al.
Res Sq . 2024 Aug; PMID: 39149479
The mammalian cerebral cortex comprises a complex neuronal network that maintains a delicate balance between excitatory neurons and inhibitory interneurons. Previous studies, including our own research, have shown that specific...
4.
Hu C, Borji M, Marrero G, Kumar V, Weir J, Kammula S, et al.
bioRxiv . 2024 Aug; PMID: 39149311
Tissue organization arises from the coordinated molecular programs of cells. Spatial genomics maps cells and their molecular programs within the spatial context of tissues. However, current methods measure spatial information...
5.
Wu S, Dai M, Yang S, McCann C, Qiu Y, Marrero G, et al.
bioRxiv . 2024 Jul; PMID: 39071350
The mammalian cerebral cortex comprises a complex neuronal network that maintains a delicate balance between excitatory neurons and inhibitory interneurons. Previous studies, including our own research, have shown that specific...
6.
Lackey E, Moreira L, Norton A, Hemelt M, Osorno T, Nguyen T, et al.
Neuron . 2024 May; 112(14):2333-2348.e6. PMID: 38692278
Molecular layer interneurons (MLIs) account for approximately 80% of the inhibitory interneurons in the cerebellar cortex and are vital to cerebellar processing. MLIs are thought to primarily inhibit Purkinje cells...
7.
Russell A, Weir J, Nadaf N, Shabet M, Kumar V, Kambhampati S, et al.
Nature . 2023 Dec; 625(7994):E11. PMID: 38110579
No abstract available.
8.
Russell A, Weir J, Nadaf N, Shabet M, Kumar V, Kambhampati S, et al.
Nature . 2023 Dec; 625(7993):101-109. PMID: 38093010
Recent technological innovations have enabled the high-throughput quantification of gene expression and epigenetic regulation within individual cells, transforming our understanding of how complex tissues are constructed. However, missing from these...
9.
Langlieb J, Sachdev N, Balderrama K, Nadaf N, Raj M, Murray E, et al.
Nature . 2023 Dec; 624(7991):333-342. PMID: 38092915
The function of the mammalian brain relies upon the specification and spatial positioning of diversely specialized cell types. Yet, the molecular identities of the cell types and their positions within...
10.
Chen C, Newman L, Stark A, Bond K, Zhang D, Nardone S, et al.
Nat Neurosci . 2023 Nov; 26(11):1929-1941. PMID: 37919612
In addition to its motor functions, the cerebellum is involved in emotional regulation, anxiety and affect. We found that suppressing the firing of cerebellar Purkinje cells (PCs) rapidly excites forebrain...