Tushar Kamath
Overview
Explore the profile of Tushar Kamath including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
628
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Recent Articles
1.
Marsh S, Walker A, Kamath T, Dissing-Olesen L, Hammond T, de Soysa T, et al.
Nat Neurosci
. 2024 Dec;
28(1):215.
PMID: 39672966
No abstract available.
2.
Gazestani V, Kamath T, Nadaf N, Dougalis A, Burris S, Rooney B, et al.
Cell
. 2023 Sep;
186(20):4438-4453.e23.
PMID: 37774681
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human postmortem samples and model organisms. Here, we generated a single-nucleus atlas from a rare cohort of cortical biopsies from...
3.
Maury E, Sherman M, Genovese G, Gilgenast T, Kamath T, Burris S, et al.
Cell Genom
. 2023 Aug;
3(8):100356.
PMID: 37601975
While germline copy-number variants (CNVs) contribute to schizophrenia (SCZ) risk, the contribution of somatic CNVs (sCNVs)-present in some but not all cells-remains unknown. We identified sCNVs using blood-derived genotype arrays...
4.
Dolan M, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, et al.
Nat Immunol
. 2023 Jul;
24(8):1382-1390.
PMID: 37500887
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes known as states. Understanding state function, especially...
5.
Gazestani V, Kamath T, Nadaf N, Burris S, Rooney B, Junkkari A, et al.
bioRxiv
. 2023 Jun;
PMID: 37333365
Cellular perturbations underlying Alzheimer's disease are primarily studied in human postmortem samples and model organisms. Here we generated a single-nucleus atlas from a rare cohort of cortical biopsies from living...
6.
Kamath T, Macosko E
Mov Disord
. 2023 Mar;
38(4):518-525.
PMID: 36881930
Parkinson's disease (PD) is pathologically defined by the death of dopaminergic (DA) neurons within the pars compacta of the substantia nigra. To date, the cause of this multifaceted disease remains...
7.
Kamath T, Abdulraouf A, Burris S, Langlieb J, Gazestani V, Nadaf N, et al.
Nat Neurosci
. 2022 May;
25(5):588-595.
PMID: 35513515
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular features associated with DA neuron...
8.
Marsh S, Walker A, Kamath T, Dissing-Olesen L, Hammond T, de Soysa T, et al.
Nat Neurosci
. 2022 Mar;
25(3):306-316.
PMID: 35260865
A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues into single-cell suspensions. While many protocols have been optimized for optimal cell yield, they have often...
9.
Wang J, Kamath T, Mazur C, Mirzamohammadi F, Rotter D, Hojo H, et al.
Nat Commun
. 2021 Nov;
12(1):6271.
PMID: 34725346
Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing osteocytes. The circuitry that drives dendrite formation during "osteocytogenesis" is poorly understood. Here we show that deletion of Sp7...
10.
Viswanathan S, Ha G, Hoff A, Wala J, Carrot-Zhang J, Whelan C, et al.
Cell
. 2018 Jun;
174(2):433-447.e19.
PMID: 29909985
Nearly all prostate cancer deaths are from metastatic castration-resistant prostate cancer (mCRPC), but there have been few whole-genome sequencing (WGS) studies of this disease state. We performed linked-read WGS on...