Alan H Shih
Overview
Explore the profile of Alan H Shih including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
37
Citations
2790
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
21.
Inoue S, Li W, Tseng A, Beerman I, Elia A, Bendall S, et al.
Cancer Cell
. 2016 Jul;
30(2):337-348.
PMID: 27424808
Mutations in the isocitrate dehydrogenase-1 gene (IDH1) are common drivers of acute myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 mutants act by...
22.
Hatlen M, Arora K, Vacic V, Grabowska E, Liao W, Riley-Gillis B, et al.
J Exp Med
. 2015 Dec;
213(1):25-34.
PMID: 26666262
t(8;21) is one of the most frequent chromosomal abnormalities observed in acute myeloid leukemia (AML). However, expression of AML1-ETO is not sufficient to induce transformation in vivo. Consistent with this...
23.
Meyer S, Keller M, Chiu S, Koppikar P, Guryanova O, Rapaport F, et al.
Cancer Cell
. 2015 Jul;
28(1):15-28.
PMID: 26175413
Although clinically tested JAK inhibitors reduce splenomegaly and systemic symptoms, molecular responses are not observed in most myeloproliferative neoplasm (MPN) patients. We previously demonstrated that MPN cells become persistent to...
24.
Shih A, Jiang Y, Meydan C, Shank K, Pandey S, Barreyro L, et al.
Cancer Cell
. 2015 Apr;
27(4):502-15.
PMID: 25873173
Specific combinations of acute myeloid leukemia (AML) disease alleles, including FLT3 and TET2 mutations, confer distinct biologic features and adverse outcome. We generated mice with mutations in Tet2 and Flt3,...
25.
Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces D, et al.
Cell Rep
. 2013 Dec;
6(1):231-244.
PMID: 24373966
Hematopoietic stem cell differentiation involves the silencing of self-renewal genes and induction of a specific transcriptional program. Identification of multiple covalent cytosine modifications raises the question of how these derivatized...
26.
Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung Y, et al.
J Exp Med
. 2013 Nov;
210(12):2641-59.
PMID: 24218140
Somatic Addition of Sex Combs Like 1 (ASXL1) mutations occur in 10-30% of patients with myeloid malignancies, most commonly in myelodysplastic syndromes (MDSs), and are associated with adverse outcome. Germline...
27.
Deplus R, Delatte B, Schwinn M, Defrance M, Mendez J, Murphy N, et al.
EMBO J
. 2013 Jan;
32(5):645-55.
PMID: 23353889
TET proteins convert 5-methylcytosine to 5-hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to epigenetic repression complexes, yet mechanistic information, especially...
28.
Shih A, Chung S, Dolezal E, Zhang S, Abdel-Wahab O, Park C, et al.
Haematologica
. 2013 Jan;
98(6):908-12.
PMID: 23349305
Therapy-related myelodysplastic syndromes and acute myelogenous leukemia comprise a poor-risk subset of myelodysplastic syndromes and acute myelogenous leukemia. Large-scale mutation profiling efforts in de novo myelodysplastic syndromes have identified mutations...
29.
Shih A, Levine R
Cancer Cell
. 2012 Sep;
22(3):285-7.
PMID: 22975371
The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic...
30.
Shih A, Abdel-Wahab O, Patel J, Levine R
Nat Rev Cancer
. 2012 Aug;
12(9):599-612.
PMID: 22898539
Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). In some cases these...