Alan H Shih
Overview
Explore the profile of Alan H Shih including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
37
Citations
2790
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Chen D, Xia S, Wang M, Lin R, Li Y, Mao H, et al.
Cancer Discov
. 2019 Mar;
9(6):756-777.
PMID: 30862724
Isocitrate dehydrogenase 1 (IDH1) is important for reductive carboxylation in cancer cells, and the IDH1 R132H mutation plays a pathogenic role in cancers including acute myeloid leukemia (AML). However, the...
12.
Harding J, Lowery M, Shih A, Schvartzman J, Hou S, Famulare C, et al.
Cancer Discov
. 2018 Oct;
8(12):1540-1547.
PMID: 30355724
Somatic mutations in cytosolic or mitochondrial isoforms of isocitrate dehydrogenase ( or , respectively) contribute to oncogenesis via production of the metabolite 2-hydroxyglutarate (2HG). Isoform-selective IDH inhibitors suppress 2HG production...
13.
Dominguez P, Ghamlouch H, Rosikiewicz W, Kumar P, Beguelin W, Fontan L, et al.
Cancer Discov
. 2018 Oct;
8(12):1632-1653.
PMID: 30274972
somatic mutations occur in ∼10% of diffuse large B-cell lymphomas (DLBCL) but are of unknown significance. Herein, we show that TET2 is required for the humoral immune response and is...
14.
McKenney A, Lau A, Hanasoge Somasundara A, Spitzer B, Intlekofer A, Ahn J, et al.
J Clin Invest
. 2018 Sep;
128(10):4743.
PMID: 30222137
No abstract available.
15.
Intlekofer A, Shih A, Wang B, Nazir A, Rustenburg A, Albanese S, et al.
Nature
. 2018 Jun;
559(7712):125-129.
PMID: 29950729
Somatic mutations in the isocitrate dehydrogenase 2 gene (IDH2) contribute to the pathogenesis of acute myeloid leukaemia (AML) through the production of the oncometabolite 2-hydroxyglutarate (2HG). Enasidenib (AG-221) is an...
16.
McKenney A, Lau A, Hanasoge Somasundara A, Spitzer B, Intlekofer A, Ahn J, et al.
J Clin Invest
. 2018 Jan;
128(2):789-804.
PMID: 29355841
Patients with myeloproliferative neoplasms (MPNs) frequently progress to bone marrow failure or acute myeloid leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are...
17.
Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, et al.
Cancer Cell
. 2017 Dec;
33(1):44-59.e8.
PMID: 29275866
Mutations in epigenetic modifiers and signaling factors often co-occur in myeloid malignancies, including TET2 and NRAS mutations. Concurrent Tet2 loss and Nras expression in hematopoietic cells induced myeloid transformation, with...
18.
Shih A, Meydan C, Shank K, Garrett-Bakelman F, Ward P, Intlekofer A, et al.
Cancer Discov
. 2017 Feb;
7(5):494-505.
PMID: 28193779
Genomic studies in acute myeloid leukemias (AML) have identified mutations that drive altered DNA methylation, including and Here, we show that models of AML resulting from or mutations combined with...
19.
Kunimoto H, McKenney A, Meydan C, Shank K, Nazir A, Rapaport F, et al.
Blood
. 2017 Jan;
129(13):1779-1790.
PMID: 28077417
Recent studies have reported that activation-induced cytidine deaminase (AID) and ten-eleven-translocation (TET) family members regulate active DNA demethylation. Genetic alterations of occur in myeloid malignancies, and hematopoietic-specific loss of induces...
20.
Han D, Lu X, Shih A, Nie J, You Q, Xu M, et al.
Mol Cell
. 2016 Aug;
63(4):711-719.
PMID: 27477909
We present a highly sensitive and selective chemical labeling and capture approach for genome-wide profiling of 5-hydroxylmethylcytosine (5hmC) using DNA isolated from ∼1,000 cells (nano-hmC-Seal). Using this technology, we assessed...