Adrianus M C H van den Nieuwendijk
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Explore the profile of Adrianus M C H van den Nieuwendijk including associated specialties, affiliations and a list of published articles.
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27
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450
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Recent Articles
11.
Nabuurs R, Kapoerchan V, Metaxas A, Hafith S, de Backer M, Welling M, et al.
Bioorg Med Chem
. 2016 Nov;
24(23):6139-6148.
PMID: 27838168
Detection of cerebral β-amyloid (Aβ) by targeted contrast agents is of great interest for in vivo diagnosis of Alzheimer's disease (AD). Partly because of their planar structure several bis-styrylbenzenes have...
12.
Stolze S, Liu N, Wijdeven R, Tuin A, van den Nieuwendijk A, Florea B, et al.
Mol Biosyst
. 2016 May;
12(6):1809-17.
PMID: 27138522
The profiling of kinases using established proteomics techniques is hampered by their non-covalent mode-of-action. One way to overcome this caveat is the use of probes featuring photo-labelling groups that can...
13.
de Bruin G, Mock E, Hoogendoorn S, van den Nieuwendijk A, Mazurek J, van der Marel G, et al.
Chem Commun (Camb)
. 2016 Feb;
52(21):4064-7.
PMID: 26894389
The incorporation of adamantylalanine and carboranylalanine at the P2 site of bortezomib is well tolerated and provided potent cell permeable proteasome inhibitors with increased off-rates compared to bortezomib. Adamantylalanine and...
14.
Ogasawara D, Deng H, Viader A, Baggelaar M, Breman A, den Dulk H, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
113(1):26-33.
PMID: 26668358
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes...
15.
Wisse P, de Geus M, Cross G, van den Nieuwendijk A, van Rooden E, van den Berg R, et al.
J Org Chem
. 2015 Jun;
80(14):7258-65.
PMID: 26061009
In this paper, a new synthetic route toward 6-hydroxysphingosine and α-hydroxy ceramide is described. The synthesis employs a cross-metathesis to unite a sphingosine head allylic alcohol with a long-chain fatty...
16.
Ghisaidoobe A, van den Berg R, Butt S, Strijland A, Donker-Koopman W, Scheij S, et al.
J Med Chem
. 2014 Sep;
57(21):9096-104.
PMID: 25250725
This work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits as dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. Building on our previous work, we synthesized a series...
17.
Witte M, Kallemeijn W, Aten J, Li K, Strijland A, Donker-Koopman W, et al.
Nat Chem Biol
. 2010 Nov;
6(12):907-13.
PMID: 21079602
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to...
18.
van den Nieuwendijk A, Ruben M, Engelsma S, Risseeuw M, van den Berg R, Boot R, et al.
Org Lett
. 2010 Aug;
12(17):3957-9.
PMID: 20690611
The chemoenzymatic synthesis of three 1-deoxynojirimycin-type iminosugars is reported. Key steps in the synthetic scheme include a Dibal reduction-transimination-sodium borohydride reduction cascade of reactions on an enantiomerically pure cyanohydrin, itself...
19.
Geurink P, Liu N, Spaans M, Downey S, van den Nieuwendijk A, van der Marel G, et al.
J Med Chem
. 2010 Feb;
53(5):2319-23.
PMID: 20131905
Proteasomal processing is conducted by three individual catalytic subunits, namely beta1, beta2, and beta5. Subunit-specific inhibitors are useful tools in dissecting the role of these individual subunits and are leads...
20.
Verdoes M, Florea B, van der Linden W, Renou D, van den Nieuwendijk A, van der Marel G, et al.
Org Biomol Chem
. 2007 Apr;
5(9):1416-26.
PMID: 17464411
The synthesis and evaluation of hybrid proteasome inhibitors that contain structural elements of the known inhibitors bortezomib, epoxomicin and peptide vinyl sulfones is described. From the panel of 15 inhibitors...