Adrianus M C H van den Nieuwendijk
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Explore the profile of Adrianus M C H van den Nieuwendijk including associated specialties, affiliations and a list of published articles.
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27
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450
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Recent Articles
1.
Thaler M, Ofman T, Kok K, Heming J, Moran E, Pickles I, et al.
ACS Cent Sci
. 2024 Sep;
10(8):1594-1608.
PMID: 39220688
The combined inhibition of endoplasmic reticulum (ER) α-glucosidases I and II has been shown to inhibit replication of a broad range of viruses that rely on ER protein quality control....
2.
Chen Y, van den Nieuwendijk A, Wu L, Moran E, Skoulikopoulou F, van Riet V, et al.
J Am Chem Soc
. 2023 Dec;
146(1):125-133.
PMID: 38118176
Siastatin B is a potent and effective iminosugar inhibitor of three diverse glycosidase classes, namely, sialidases, β--glucuronidases, and -acetyl-glucosaminidases. The mode of inhibition of glucuronidases, in contrast to sialidases, has...
3.
Kuo C, Su Q, van den Nieuwendijk A, Beenakker T, Offen W, Willems L, et al.
Org Biomol Chem
. 2023 Sep;
21(38):7813-7820.
PMID: 37724332
Acid β-galactosidase (GLB1) and galactocerebrosidase (GALC) are retaining exo-β-galactosidases involved in lysosomal glycoconjugate metabolism. Deficiency of GLB1 may result in the lysosomal storage disorders GM1 gangliosidosis, Morquio B syndrome, and...
4.
Rowland R, Chen Y, Breen I, Wu L, Offen W, Beenakker T, et al.
Chemistry
. 2021 Sep;
27(66):16377-16388.
PMID: 34570911
Gaucher disease (GD) is a lysosomal storage disorder caused by inherited deficiencies in β-glucocerebrosidase (GBA). Current treatments require rapid disease diagnosis and a means of monitoring therapeutic efficacy, both of...
5.
Artola M, Wouters S, Schroder S, de Boer C, Chen Y, Petracca R, et al.
European J Org Chem
. 2019 Dec;
2019(6):1397-1404.
PMID: 31787842
Cyclophellitol aziridine and its configurational and functional isomers are powerful covalent inhibitors of retaining glycosidases, and find application in fundamental studies on glycosidases, amongst others in relation to inherited lysosomal...
6.
Grimm S, Gagestein B, Keijzer J, Liu N, Wijdeven R, Lenselink E, et al.
Bioorg Med Chem
. 2019 Jan;
27(5):692-699.
PMID: 30661740
Acute myeloid leukemia (AML) is characterized by fast progression and low survival rates, in which Fms-like tyrosine kinase 3 (FLT3) receptor mutations have been identified as a driver mutation in...
7.
Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors
Deng H, van der Wel T, van den Berg R, van den Nieuwendijk A, Janssen F, Baggelaar M, et al.
Medchemcomm
. 2018 Aug;
8(5):982-988.
PMID: 30108813
Inhibitors of diacylglycerol lipases and α,β-hydrolase domain containing protein 6 (ABHD6) are potential leads for the development of therapeutic agents for metabolic and neurodegenerative disorders. Here, we report the enantioselective...
8.
Jiang J, Kallemeijn W, Wright D, van den Nieuwendijk A, Rohde V, Folch E, et al.
Chem Sci
. 2017 Nov;
6(5):2782-false.
PMID: 29142681
GH29 α-l-fucosidases catalyze the hydrolysis of α-l-fucosidic linkages. Deficiency in human lysosomal α-l-fucosidase (FUCA1) leads to the recessively inherited disorder, fucosidosis. Herein we describe the development of fucopyranose-configured cyclophellitol aziridines...
9.
Lahav D, Liu B, van den Berg R, van den Nieuwendijk A, Wennekes T, Ghisaidoobe A, et al.
J Am Chem Soc
. 2017 Sep;
139(40):14192-14197.
PMID: 28937220
Human nonlysosomal glucosylceramidase (GBA2) is one of several enzymes that controls levels of glycolipids and whose activity is linked to several human disease states. There is a major need to...
10.
Deng H, Kooijman S, van den Nieuwendijk A, Ogasawara D, van der Wel T, van Dalen F, et al.
J Med Chem
. 2016 Dec;
60(1):428-440.
PMID: 27992221
Triazole ureas constitute a versatile class of irreversible inhibitors that target serine hydrolases in both cells and animal models. We have previously reported that triazole ureas can act as selective...