Clara C Posthuma
Overview
Explore the profile of Clara C Posthuma including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
31
Citations
2334
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ogando N, El Kazzi P, Zevenhoven-Dobbe J, Bontes B, Decombe A, Posthuma C, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(49).
PMID: 34845015
As coronaviruses (CoVs) replicate in the host cell cytoplasm, they rely on their own capping machinery to ensure the efficient translation of their messenger RNAs (mRNAs), protect them from degradation...
2.
Ogando N, Zevenhoven-Dobbe J, van der Meer Y, Bredenbeek P, Posthuma C, Snijder E
J Virol
. 2020 Sep;
94(23).
PMID: 32938769
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3'-to-5' exoribonuclease (ExoN) and guanine-N7-methyltransferase (N7-MTase) domains. While...
3.
Ogando N, Ferron F, Decroly E, Canard B, Posthuma C, Snijder E
Front Microbiol
. 2019 Aug;
10:1813.
PMID: 31440227
Among RNA viruses, the order stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps)....
4.
Yoon J, Kim G, Jarhad D, Kim H, Shin Y, Qu S, et al.
J Med Chem
. 2019 Jun;
62(13):6346-6362.
PMID: 31244113
The 6'-fluorinated aristeromycins were designed as dual-target antiviral compounds aimed at inhibiting both the viral RNA-dependent RNA polymerase (RdRp) and the host cell -adenosyl-l-homocysteine (SAH) hydrolase, which would indirectly target...
5.
de Wilde A, Boomaars-van der Zanden A, de Jong A, Barcena M, Snijder E, Posthuma C
J Virol
. 2019 Jun;
93(18).
PMID: 31243130
Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the order In...
6.
de Wilde A, Pham U, Posthuma C, Snijder E
Virology
. 2018 Jul;
522:46-55.
PMID: 30014857
Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs,...
7.
de Wilde A, Zevenhoven-Dobbe J, Beugeling C, Chatterji U, de Jong D, Gallay P, et al.
Virology
. 2017 Dec;
517:148-156.
PMID: 29249267
Cyclophilin A (CypA) is an important host factor in the replication of a variety of RNA viruses. Also the replication of several nidoviruses was reported to depend on CypA, although...
8.
Tuijtel M, Mulder A, Posthuma C, van der Hoeven B, Koster A, Barcena M, et al.
Sci Rep
. 2017 Sep;
7(1):10442.
PMID: 28874723
Correlative light-electron microscopy (CLEM) combines the high spatial resolution of transmission electron microscopy (TEM) with the capability of fluorescence light microscopy (FLM) to locate rare or transient cellular events within...
9.
Posthuma C, Te Velthuis A, Snijder E
Virus Res
. 2017 Feb;
234:58-73.
PMID: 28174054
Coronaviruses and arteriviruses are distantly related human and animal pathogens that belong to the order Nidovirales. Nidoviruses are characterized by their polycistronic plus-stranded RNA genome, the production of subgenomic mRNAs...
10.
de Wilde A, Falzarano D, Zevenhoven-Dobbe J, Beugeling C, Fett C, Martellaro C, et al.
Virus Res
. 2016 Nov;
228:7-13.
PMID: 27840112
Currently, there is no registered treatment for infections with emerging zoonotic coronaviruses like SARS- and MERS-coronavirus. We here report that in cultured cells low-micromolar concentrations of alisporivir, a non-immunosuppressive cyclosporin...