Adam Skepner
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Explore the profile of Adam Skepner including associated specialties, affiliations and a list of published articles.
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9
Citations
161
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Recent Articles
1.
Jiang W, Shaw S, Rush J, Dumont N, Kim J, Singh R, et al.
bioRxiv
. 2024 Jun;
PMID: 38826457
Protein phosphatase, Mg/Mn dependent 1D (PPM1D), is a serine/threonine phosphatase that is recurrently activated in cancer, regulates the DNA damage response (DDR), and suppresses the activation of p53. Consistent with...
2.
Chandrasekaran S, Cimini B, Goodale A, Miller L, Kost-Alimova M, Jamali N, et al.
Nat Methods
. 2024 Apr;
21(6):1114-1121.
PMID: 38594452
The identification of genetic and chemical perturbations with similar impacts on cell morphology can elucidate compounds' mechanisms of action or novel regulators of genetic pathways. Research on methods for identifying...
3.
Cimini B, Chandrasekaran S, Kost-Alimova M, Miller L, Goodale A, Fritchman B, et al.
Nat Protoc
. 2023 Jun;
18(7):1981-2013.
PMID: 37344608
In image-based profiling, software extracts thousands of morphological features of cells from multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used for basic research and drug discovery. Powerful...
4.
Dagher M, Ongo G, Robichaud N, Kong J, Rho W, Teahulos I, et al.
bioRxiv
. 2023 May;
PMID: 37131604
We present the nELISA, a high-throughput, high-fidelity, and high-plex protein profiling platform. DNA oligonucleotides are used to pre-assemble antibody pairs on spectrally encoded microparticles and perform displacement-mediated detection. Spatial separation...
5.
Mulvaney K, Blomquist C, Acharya N, Li R, Ranaghan M, OKeefe M, et al.
Mol Cell
. 2021 Aug;
81(17):3481-3495.e7.
PMID: 34358446
PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP-null cancers. PRMT5 uses adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily...
6.
McKinney D, McMillan B, Ranaghan M, Moroco J, Brousseau M, Mullin-Bernstein Z, et al.
J Med Chem
. 2021 Aug;
64(15):11148-11168.
PMID: 34342224
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to...
7.
Chiang W, Wei Y, Kuo Y, Wei S, Zhou A, Zou Z, et al.
ACS Chem Biol
. 2018 Jun;
13(8):2247-2260.
PMID: 29878747
Autophagy, a lysosomal degradation pathway, plays a crucial role in cellular homeostasis, development, immunity, tumor suppression, metabolism, prevention of neurodegeneration, and lifespan extension. Thus, pharmacological stimulation of autophagy may be...
8.
Weiwer M, Xu Q, Gale J, Lewis M, Campbell A, Schroeder F, et al.
ACS Chem Biol
. 2018 Feb;
13(4):1038-1047.
PMID: 29485852
Schizophrenia is a severe neuropsychiatric disease that lacks completely effective and safe therapies. As a polygenic disorder, genetic studies have only started to shed light on its complex etiology. To...
9.
Nemirovskiy O, Zheng Y, Tung D, Korniski B, Settle S, Skepner A, et al.
Xenobiotica
. 2010 Jun;
40(8):586-92.
PMID: 20509748
Osteoarthritis (OA) is a degenerative joint disease that has no FDA-approved treatment. The current standard of care does not address the regeneration of the damaged cartilage. Human growth hormone (hGH)...