David C McKinney
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Explore the profile of David C McKinney including associated specialties, affiliations and a list of published articles.
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15
Citations
188
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Recent Articles
1.
Jiang W, Shaw S, Rush J, Dumont N, Kim J, Singh R, et al.
bioRxiv
. 2024 Jun;
PMID: 38826457
Protein phosphatase, Mg/Mn dependent 1D (PPM1D), is a serine/threonine phosphatase that is recurrently activated in cancer, regulates the DNA damage response (DDR), and suppresses the activation of p53. Consistent with...
2.
Mulvaney K, Blomquist C, Acharya N, Li R, Ranaghan M, OKeefe M, et al.
Mol Cell
. 2021 Aug;
81(17):3481-3495.e7.
PMID: 34358446
PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP-null cancers. PRMT5 uses adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily...
3.
McKinney D, McMillan B, Ranaghan M, Moroco J, Brousseau M, Mullin-Bernstein Z, et al.
J Med Chem
. 2021 Aug;
64(15):11148-11168.
PMID: 34342224
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to...
4.
McKinney D, Eyermann C, Gu R, Hu J, Kazmirski S, Lahiri S, et al.
ACS Infect Dis
. 2016 Sep;
2(7):456-64.
PMID: 27626097
Fatty acid biosynthesis is essential to bacterial growth in Gram-negative pathogens. Several small molecules identified through a combination of high-throughput and fragment screening were cocrystallized with FabH (β-ketoacyl-acyl carrier protein...
5.
McKinney D, Zhou F, Eyermann C, Ferguson A, Prince D, Breen J, et al.
ACS Infect Dis
. 2016 Sep;
1(7):310-6.
PMID: 27622821
Bacterially expressed β-lactamases are rapidly eroding the clinical utility of the important β-lactam class of antibacterials, significantly impairing our ability to fight serious bacterial infections. This paper describes a study...
6.
McKinney D, Bezdenejnih-Snyder N, Farrington K, Guo J, McLaughlin R, Ruvinsky A, et al.
ACS Infect Dis
. 2016 Sep;
1(5):222-30.
PMID: 27622650
Negamycin is a hydrophilic antimicrobial translation inhibitor that crosses the lipophilic inner membrane of Escherichia coli via at least two transport routes to reach its intracellular target. In a minimal...
7.
McKinney D, Basarab G, Cocozaki A, Foulk M, Miller M, Ruvinsky A, et al.
ACS Med Chem Lett
. 2015 Aug;
6(8):930-5.
PMID: 26288696
Negamycin is a natural product with antibacterial activity against a broad range of Gram-negative pathogens. Recent revelation of its ribosomal binding site and mode of inhibition has reinvigorated efforts to...
8.
Rose J, Lahiri S, McKinney D, Albert R, Morningstar M, Shapiro A, et al.
Bioorg Med Chem Lett
. 2015 Jun;
25(16):3301-6.
PMID: 26099541
With increasing emergence of multi-drug resistant infections, there is a dire need for new classes of compounds that act through unique mechanisms. In this work, we describe the discovery and...
9.
Molodtsov V, Fleming P, Eyermann C, Ferguson A, Foulk M, McKinney D, et al.
J Med Chem
. 2015 Mar;
58(7):3156-71.
PMID: 25798859
Squaramides constitute a novel class of RNA polymerase inhibitors of which genetic evidence and computational modeling previously have suggested an inhibitory mechanism mediated by binding to the RNA polymerase switch...
10.
Hameed P S, Manjrekar P, Chinnapattu M, Humnabadkar V, Shanbhag G, Kedari C, et al.
ACS Chem Biol
. 2014 Jul;
9(10):2274-82.
PMID: 25035921
The bacterial peptidoglycan biosynthesis pathway provides multiple targets for antibacterials, as proven by the clinical success of β-lactam and glycopeptide classes of antibiotics. The Mur ligases play an essential role...