Maria Kost-Alimova
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Explore the profile of Maria Kost-Alimova including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Kim C, Gabriel K, Boone D, Brown M, Oppenheimer K, Kost-Alimova M, et al.
bioRxiv
. 2025 Jan;
PMID: 39763943
Exposure to saturated fatty acids (SFAs), such as palmitic acid, can lead to cellular metabolic dysfunction known as lipotoxicity. Although canonical adaptive metabolic processes like lipid storage or desaturation are...
2.
Bazua-Valenti S, Brown M, Zavras J, Riedl Khursigara M, Grinkevich E, Sidhom E, et al.
J Clin Invest
. 2024 Dec;
134(24).
PMID: 39680459
The trafficking dynamics of uromodulin (UMOD), the most abundant protein in human urine, play a critical role in the pathogenesis of kidney disease. Monoallelic mutations in the UMOD gene cause...
3.
Chandrasekaran S, Cimini B, Goodale A, Miller L, Kost-Alimova M, Jamali N, et al.
Nat Methods
. 2024 Apr;
21(6):1114-1121.
PMID: 38594452
The identification of genetic and chemical perturbations with similar impacts on cell morphology can elucidate compounds' mechanisms of action or novel regulators of genetic pathways. Research on methods for identifying...
4.
Laber S, Strobel S, Mercader J, Dashti H, Dos Santos F, Kubitz P, et al.
Cell Genom
. 2023 Jul;
3(7):100346.
PMID: 37492099
A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by genetic risk variants and effector genes. Here, we introduce LipocyteProfiler, a...
5.
Cimini B, Chandrasekaran S, Kost-Alimova M, Miller L, Goodale A, Fritchman B, et al.
Nat Protoc
. 2023 Jun;
18(7):1981-2013.
PMID: 37344608
In image-based profiling, software extracts thousands of morphological features of cells from multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used for basic research and drug discovery. Powerful...
6.
Dagher M, Ongo G, Robichaud N, Kong J, Rho W, Teahulos I, et al.
bioRxiv
. 2023 May;
PMID: 37131604
We present the nELISA, a high-throughput, high-fidelity, and high-plex protein profiling platform. DNA oligonucleotides are used to pre-assemble antibody pairs on spectrally encoded microparticles and perform displacement-mediated detection. Spatial separation...
7.
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al.
Cell Metab
. 2023 Apr;
35(5):887-905.e11.
PMID: 37075753
Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-associated diseases. However, there are no scalable approaches to comprehensively assess the diverse FFAs circulating in human...
8.
Wieder N, Fried J, Kim C, Sidhom E, Brown M, Marshall J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865221
Highlights: FALCON (Fatty Acid Library for Comprehensive ONtologies) enables multimodal profiling of 61 free fatty acids (FFAs) to reveal 5 FFA clusters with distinct biological effectsFALCON is applicable to many...
9.
Way G, Natoli T, Adeboye A, Litichevskiy L, Yang A, Lu X, et al.
Cell Syst
. 2022 Nov;
13(11):911-923.e9.
PMID: 36395727
Morphological and gene expression profiling can cost-effectively capture thousands of features in thousands of samples across perturbations by disease, mutation, or drug treatments, but it is unclear to what extent...
10.
Chaffin M, Papangeli I, Simonson B, Akkad A, Hill M, Arduini A, et al.
Nature
. 2022 Jun;
608(7921):174-180.
PMID: 35732739
Heart failure encompasses a heterogeneous set of clinical features that converge on impaired cardiac contractile function and presents a growing public health concern. Previous work has highlighted changes in both...