Anne E Carpenter
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Explore the profile of Anne E Carpenter including associated specialties, affiliations and a list of published articles.
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14518
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Recent Articles
1.
Serrano E, Chandrasekaran S, Bunten D, Brewer K, Tomkinson J, Kern R, et al.
Nat Methods
. 2025 Mar;
PMID: 40032995
Advances in high-throughput microscopy have enabled the rapid acquisition of large numbers of high-content microscopy images. Next, whether by deep learning or classical algorithms, image analysis pipelines commonly produce single-cell...
2.
Ewald J, Titterton K, Bauerle A, Beatson A, Boiko D, Cabrera A, et al.
bioRxiv
. 2025 Feb;
PMID: 39896617
High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed for better decision-making in human health. Here, we apply image-based profiling (the Cell Painting assay) and two cytotoxicity assays (metabolic...
3.
Ramezani M, Weisbart E, Bauman J, Singh A, Yong J, Lozada M, et al.
Nat Methods
. 2025 Jan;
22(3):621-633.
PMID: 39870862
A key challenge of the modern genomics era is developing empirical data-driven representations of gene function. Here we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing...
4.
Navidi Z, Ma J, Miglietta E, Liu L, Carpenter A, Cimini B, et al.
bioRxiv
. 2025 Jan;
PMID: 39763991
Understanding cellular responses to external stimuli is critical for parsing biological mechanisms and advancing therapeutic development. High-content image-based assays provide a cost-effective approach to examine cellular phenotypes induced by diverse...
5.
Seal S, Trapotsi M, Spjuth O, Singh S, Carreras-Puigvert J, Greene N, et al.
Nat Methods
. 2024 Dec;
22(2):447.
PMID: 39668211
No abstract available.
6.
Seal S, Trapotsi M, Spjuth O, Singh S, Carreras-Puigvert J, Greene N, et al.
Nat Methods
. 2024 Dec;
22(2):254-268.
PMID: 39639168
Modern quantitative image analysis techniques have enabled high-throughput, high-content imaging experiments. Image-based profiling leverages the rich information in images to identify similarities or differences among biological samples, rather than measuring...
7.
Tegtmeyer M, Liyanage D, Han Y, Hebert K, Pei R, Way G, et al.
bioRxiv
. 2024 Nov;
PMID: 39605350
Neuropsychiatric conditions pose substantial challenges for therapeutic development due to their complex and poorly understood underlying mechanisms. High-throughput, unbiased phenotypic assays present a promising path for advancing therapeutic discovery, especially...
8.
van Dijk R, Arevalo J, Babadi M, Carpenter A, Singh S
PLoS Comput Biol
. 2024 Nov;
20(11):e1012547.
PMID: 39527652
Image-based cell profiling is a powerful tool that compares perturbed cell populations by measuring thousands of single-cell features and summarizing them into profiles. Typically a sample is represented by averaging...
9.
Lacoste J, Haghighi M, Haider S, Reno C, Lin Z, Segal D, et al.
Cell
. 2024 Oct;
187(23):6725-6741.e13.
PMID: 39353438
Widespread sequencing has yielded thousands of missense variants predicted or confirmed as disease causing. This creates a new bottleneck: determining the functional impact of each variant-typically a painstaking, customized process...
10.
Garcia-Fossa F, Moraes-Lacerda T, Rodrigues-da-Silva M, Diaz-Rohrer B, Singh S, Carpenter A, et al.
bioRxiv
. 2024 Sep;
PMID: 39257795
Image-based profiling has been used to analyze cell health, drug mechanism of action, CRISPR-edited cells, and overall cytotoxicity. Cell Painting is a broadly used image-based assay that uses morphological features...