A E Eakin
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Explore the profile of A E Eakin including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
297
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Recent Articles
1.
Rizk M, Bhavnani S, Drusano G, Dane A, Eakin A, Guina T, et al.
Antimicrob Agents Chemother
. 2019 Mar;
63(5).
PMID: 30833427
In June 2017, The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, organized a workshop entitled "Pharmacokinetics-Pharmacodynamics (PK/PD) for Development of Therapeutics against Bacterial...
2.
Barnes B, Izydore R, Eakin A, Hall I
Int J Cancer
. 2001 Oct;
94(2):275-81.
PMID: 11668509
The observation that expression of the IMPDH gene is tightly linked with cellular proliferation and transformation has led to an interest in developing inhibitors that deplete intracellular guanine nucleotide pools....
3.
Lee C, Medrano F, Craig 3rd S, Eakin A
Biochim Biophys Acta
. 2001 Jul;
1537(1):63-70.
PMID: 11476964
Hypoxanthine phosphoribosyltransferases (HPRTs) are of biomedical interest because defects in the enzyme from humans can result in gouty arthritis or Lesch-Nyhan syndrome, and in parasites these enzymes are potential targets...
4.
Barnes B, Izydore R, Eakin A, Hall I
J Pharmacol Exp Ther
. 2001 Jul;
298(2):790-6.
PMID: 11454943
Inosine 5'-monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in the de novo pathway for synthesis of guanine nucleotides, is essential for normal cell proliferation and function. New derivatives of the 1,5-diazabicyclo[3.1.0]hexane-2,4-diones...
5.
Barnes B, Eakin A, Izydore R, Hall I
Biochem Pharmacol
. 2001 May;
62(1):91-100.
PMID: 11377400
It was shown previously that three 1,5-diazabicyclo[3.1.0]hexane-2,4-diones selectively inhibited human Type II IMP dehydrogenase (IMPDH) from Tmolt4 cell leukemia [Barnes et al., Biochemistry 2000;39:13641-50]. The agents acted as competitive inhibitors...
6.
Canyuk B, Focia P, Eakin A
Biochemistry
. 2001 Mar;
40(9):2754-65.
PMID: 11258886
The role of an invariant aspartic acid (Asp137) in hypoxanthine phosphoribosyltransferases (HPRTs) was examined by site-directed and saturation mutagenesis, functional analysis, and X-ray crystallography using the HPRT from Trypanosoma cruzi....
7.
Freymann D, Wenck M, Engel J, Feng J, Focia P, Eakin A, et al.
Chem Biol
. 2001 Jan;
7(12):957-68.
PMID: 11137818
Background: Currently, only two drugs are recommended for treatment of infection with Trypanosoma cruzi, the etiologic agent of Chagas' disease. These compounds kill the trypomastigote forms of the parasite circulating...
8.
Barnes B, Eakin A, Izydore R, Hall I
Biochemistry
. 2000 Nov;
39(45):13641-50.
PMID: 11076502
Inosine 5'-monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in de novo purine biosynthesis. IMPDH activity results from expression of two isoforms. Type I is constitutively expressed and predominates in normal...
9.
10.
Craig 3rd S, Eakin A
Vitam Horm
. 2000 Feb;
58:149-69.
PMID: 10668398
Time and costs associated with the discovery of new drugs have been significantly reduced by enzyme structure-based approaches to the discovery of new chemotherapeutic agents. However, fundamental components of the...