Alpha 2.0
Login Register
» Authors » R A Izydore

R A Izydore

Explore the profile of R A Izydore including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 29
Citations 37
Followers 0
Related Specialties
Pharmacology
Pharmacy
Oncology
Top 10 Co-Authors
I H Hall
O T Wong
R Simlot
B J Barnes
J R Wheaton
A E Eakin
T Woodard
M L Debnath
D L Daniels
A E Warren
Published In
Anticancer Res
Arch Pharm (Weinheim)
Pharmazie
Res Commun Chem Pathol Pharmacol
J Pharm Sci
Affiliations
Soon will be listed here.
Recent Articles
1.
Analysis of the in vitro inhibition of murine and human tumor cell growth by pyrazole derivatives and a substituted azabicyclo [3.1.0] hexane-2,4-dione
Barnes B, Izydore R, Hall I
Anticancer Res . 2001 Nov; 21(4A):2313-21. PMID: 11724288
3-Ethoxycarbonyl-5-phenyl-1, 3a, 4, 5, 6, 6a-hexahydropyrrolo[3,4-c]pyrazole-4, 6-dione, 2, 2, 6, 6-tetraethyl-1H, 5H-pyrazole[1, 2-a]pyrazole-1, 3, 5, 7-[2H, 6H]-tetraone and 6-ethoxycarbonyl-3-phenyl-3-azabicyclo[3.1.0] hexane-2, 4-dione demonstrated potent cytotoxic activity in the human Tmolt3, Tmolt4...
2.
Mechanism of action of the antitumor agents 6-benzoyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones: potent inhibitors of human type II inosine 5'-monophosphate dehydrogenase
Barnes B, Izydore R, Eakin A, Hall I
Int J Cancer . 2001 Oct; 94(2):275-81. PMID: 11668509
The observation that expression of the IMPDH gene is tightly linked with cellular proliferation and transformation has led to an interest in developing inhibitors that deplete intracellular guanine nucleotide pools....
3.
Cytotoxicity and mode of action of 1-(1-cyclohexenyl) and 1-unsubstituted 3,5-pyrazolidinediones in human Molt4 T cell leukemia
Barnes B, Izydore R, Hall I
Anticancer Res . 2001 Aug; 21(3B):1857-68. PMID: 11497269
The 3,5-pyrazolidinediones proved to be potent cytotoxic agents against the growth of a number of murine and human tumor cell lines, e.g. human THP-I monocytic leukemia, Hut-78 lymphoma, MCF-7 breast...
4.
Induction of Tmolt4 leukemia cell death by 3,3-disubstituted-6,6-pentamethylene-1,5-diazabicyclo[3.1.0]hexane-2-4-diones: specificity for type II inosine 5'-monophasphate dehydrogenase
Barnes B, Izydore R, Eakin A, Hall I
J Pharmacol Exp Ther . 2001 Jul; 298(2):790-6. PMID: 11454943
Inosine 5'-monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in the de novo pathway for synthesis of guanine nucleotides, is essential for normal cell proliferation and function. New derivatives of the 1,5-diazabicyclo[3.1.0]hexane-2,4-diones...
5.
Tmolt4 leukemic type II isoform of IMP dehydrogenase as a target for 1,2,4-triazolidine-3,5-diones, 1-(1-(3-methylphenyl)ethylidineamino)-4,4-diethyl-3,5-azetidinediones, 3,5-isoxazolidinediones, and 4,4-disubstituted-3,5-pyrazolidinediones
Hall I, Barnes B, Ward E, Wheaton J, Warren A, Izydore R
Arch Pharm (Weinheim) . 2001 May; 334(4):109-16. PMID: 11382145
The 1,2,4-triazolidine-3,5-diones, 1-(1-(3-methylphenyl)ethylidineamino)-4,4-diethyl-3,5-azetidinediones, and 4,4-disubstituted-3,5-pyrazolidinediones proved to be potent competitive inhibitors of human Tmolt4 leukemia Type II IMP dehydrogenase [IMPDH] activity, an enzyme isoform which is induced in highly proliferating...
6.
Implications of selective type II IMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death
Barnes B, Eakin A, Izydore R, Hall I
Biochem Pharmacol . 2001 May; 62(1):91-100. PMID: 11377400
It was shown previously that three 1,5-diazabicyclo[3.1.0]hexane-2,4-diones selectively inhibited human Type II IMP dehydrogenase (IMPDH) from Tmolt4 cell leukemia [Barnes et al., Biochemistry 2000;39:13641-50]. The agents acted as competitive inhibitors...
7.
Specific inhibition of type II inosine monophosphate dehydrogenase activity of Tmolt4 T cell human leukaemia cells by 3-methoxy and di-benzohydroxamic acids, maleic hydrazide and malonic acids
Hall I, Barnes B, Ward E, Wheaton J, Izydore R
J Pharm Pharmacol . 2001 May; 53(5):749-55. PMID: 11370715
Small-molecular-weight benzohydroxamic and malonic acids and maleic hydrazide proved to be potent inhibitors of the activity of human Tmolt4 leukaemia Type II IMP (inosine monophosphate) dehydrogenase (IMPDH) activity. They were...
8.
The cytotoxicity of 1-(1-phenylalkylideneamino)-2,4-azetidinediones and their mode of action in human and murine tumor cells
Izydore R, Zhang Y, Zhou X, Warren A, Wheaton J, Hall I
Anticancer Res . 2001 Apr; 21(1A):157-65. PMID: 11299729
The 1-(1-phenylalkylideneamino)-2,4-azetidinediones are potent cytotoxic agents against the growth of human and murine leukemias, lymphoma, and suspended HeLa uterine carcinoma. In cell lines cultured from solid human tumors, the agents...
9.
Cytotoxicity of 2-ethenyl-2,3-dihydrophthalazine-1,4-diones in murine and human tumor cultured cells
Hall I, Covington D, Wheaton J, Izydore R, Zhou X
Pharmazie . 2001 Mar; 56(2):168-74. PMID: 11234348
2-Etheny1-2,3-dihydrophthalazine-1,4-diones were successfully synthesized and proved to be effective cytotoxic agents against the growth of suspended murine and human leukemias and lymphomas. Selected compounds were also active in human HeLa...
10.
Selective inhibition of human Molt-4 leukemia type II inosine 5'-monophosphate dehydrogenase by the 1,5-diazabicyclo[3.1.0]hexane-2,4-diones
Barnes B, Eakin A, Izydore R, Hall I
Biochemistry . 2000 Nov; 39(45):13641-50. PMID: 11076502
Inosine 5'-monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in de novo purine biosynthesis. IMPDH activity results from expression of two isoforms. Type I is constitutively expressed and predominates in normal...