S P Craig 3rd
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Explore the profile of S P Craig 3rd including associated specialties, affiliations and a list of published articles.
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20
Citations
134
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Recent Articles
1.
Lee C, Medrano F, Craig 3rd S, Eakin A
Biochim Biophys Acta
. 2001 Jul;
1537(1):63-70.
PMID: 11476964
Hypoxanthine phosphoribosyltransferases (HPRTs) are of biomedical interest because defects in the enzyme from humans can result in gouty arthritis or Lesch-Nyhan syndrome, and in parasites these enzymes are potential targets...
2.
3.
Craig 3rd S, Eakin A
Vitam Horm
. 2000 Feb;
58:149-69.
PMID: 10668398
Time and costs associated with the discovery of new drugs have been significantly reduced by enzyme structure-based approaches to the discovery of new chemotherapeutic agents. However, fundamental components of the...
4.
Balendiran G, Molina J, Xu Y, Stevens R, Focia P, Eakin A, et al.
Protein Sci
. 1999 May;
8(5):1023-31.
PMID: 10338013
Site-directed mutagenesis was used to replace Lys68 of the human hypoxanthine phosphoribosyltransferase (HGPRTase) with alanine to exploit this less reactive form of the enzyme to gain additional insights into the...
5.
Focia P, Craig 3rd S, Eakin A
Biochemistry
. 1998 Dec;
37(49):17120-7.
PMID: 9860824
Hypoxanthine phosphoribosyltransferase (HPRT) salvages 6-oxopurine bases in the nucleotide metabolic pathway. The 1.8 A crystal structure of an asymmetric dimer of the HPRT from the protozoan parasite Trypanosoma cruzi was...
6.
Nieves-Alicea R, Focia P, Craig 3rd S, Eakin A
Biochim Biophys Acta
. 1998 Dec;
1388(2):500-5.
PMID: 9858784
Two crystal forms of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi were grown and characterized. Proteolytic modification at the C-terminus of the recombinant enzyme yielded monoclinic crystals that diffract X-rays to...
7.
Focia P, Craig 3rd S, Nieves-Alicea R, Fletterick R, Eakin A
Biochemistry
. 1998 Oct;
37(43):15066-75.
PMID: 9790669
The hypoxanthine phosphoribosyltransferase (HPRT) from Trypanosoma cruzi, etiologic agent of Chagas' disease, was cocrystallized with the inosine analogue Formycin B (FmB) and the structure determined to 1.4 A resolution. This...
8.
Canyuk B, Craig 3rd S, Eakin A
Appl Microbiol Biotechnol
. 1998 Oct;
50(2):181-6.
PMID: 9763688
A bacterial complementation assay has been developed for the rapid screening of a large number of compounds to identify those that inhibit an enzyme target for structure-based inhibitor design. The...
9.
Lee C, Craig 3rd S, Eakin A
Biochemistry
. 1998 Apr;
37(10):3491-8.
PMID: 9521670
Early studies involving purine salvage in Salmonella typhimurium resulted in the isolation and identification of a mutant strain possessing a genetically modified hypoxanthine phosphoribosyl-transferase (HPRT) with enhanced substrate specificity for...
10.
Eakin A, Guerra A, Focia P, Craig 3rd S
Antimicrob Agents Chemother
. 1997 Aug;
41(8):1686-92.
PMID: 9257742
The hypoxanthine phosphoribosyltransferase (HPRT) from Trypanosoma cruzi is a potential target for enzyme structure-based inhibitor design, based on previous studies which indicate that these parasites lack the metabolic enzymes required...