C S Craik
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Explore the profile of C S Craik including associated specialties, affiliations and a list of published articles.
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Articles
140
Citations
3301
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Recent Articles
1.
Sevillano N, Bohn M, Zimanyi M, Chen Y, Petzold C, Gupta S, et al.
Biochim Biophys Acta Proteins Proteom
. 2020 Nov;
1869(2):140562.
PMID: 33221341
Affinity maturation of U33, a recombinant Fab inhibitor of uPA, was used to improve the affinity and the inhibitory effect compared to the parental Fab. Arginine scanning of the six...
2.
McKerrow J, Doyle P, Engel J, Podust L, Robertson S, Ferreira R, et al.
Mem Inst Oswaldo Cruz
. 2009 Sep;
104 Suppl 1:263-9.
PMID: 19753483
This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of developing new drugs for the treatment...
3.
Goetz D, Choe Y, Hansell E, Chen Y, McDowell M, Jonsson C, et al.
Biochemistry
. 2007 Jul;
46(30):8744-52.
PMID: 17605471
Severe acute respiratory syndrome (SARS) is an emerging infectious disease associated with a high rate of mortality. The SARS-associated coronavirus (SARS-CoV) has been identified as the etiological agent of the...
4.
Person M, Brown K, Mahrus S, Craik C, Burlingame A
Protein Sci
. 2001 Jul;
10(8):1549-62.
PMID: 11468352
In the presence of a suitable oxidizing agent, the Ni(II) complex of glycyl-glycyl-histidine (GGH) mediates efficient and specific oxidative protein cross-linking. The fusion of GGH to the N terminus of...
5.
Harris J, Niles A, BURDICK K, Maffitt M, Backes B, Ellman J, et al.
J Biol Chem
. 2001 Jul;
276(37):34941-7.
PMID: 11438529
Tryptases betaI and betaII were heterologously expressed and purified in yeast to functionally characterize the substrate specificity of each enzyme. Three positional scanning combinatorial tetrapeptide substrate libraries were used to...
6.
Eggers C, Wang S, Fletterick R, Craik C
J Mol Biol
. 2001 May;
308(5):975-91.
PMID: 11352586
Ecotin is a homodimeric protein from Escherichia coli that inhibits many serine proteases of the chymotrypsin fold, often with little effect from the character or extent of enzyme substrate specificity....
7.
Selvarajan S, Lund L, Takeuchi T, Craik C, Werb Z
Nat Cell Biol
. 2001 Mar;
3(3):267-75.
PMID: 11231576
Here we show that plasma kallikrein (PKal) mediates a plasminogen (Plg) cascade in adipocyte differentiation. Ecotin, an inhibitor of serine proteases, inhibits cell-shape change, adipocyte-specific gene expression, and lipid accumulation...
8.
Nealon K, Newcomb W, Pray T, Craik C, Brown J, Kedes D
J Virol
. 2001 Feb;
75(6):2866-78.
PMID: 11222712
Despite the discovery of Epstein-Barr virus more than 35 years ago, a thorough understanding of gammaherpesvirus capsid composition and structure has remained elusive. We approached this problem by purifying capsids...
9.
Reiling K, Pray T, Craik C, Stroud R
Biochemistry
. 2000 Oct;
39(42):12796-803.
PMID: 11041844
The structure of Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr), at 2.2 A resolution, reveals the active-site geometry and defines multiple possible target sites for drug design against a human cancer-producing...
10.
Waugh S, Harris J, Fletterick R, Craik C
Nat Struct Biol
. 2000 Aug;
7(9):762-5.
PMID: 10966646
Granzyme B is a serine protease of the chymotrypsin fold that mediates cell death by cytotoxic lymphocytes. It is a processing enzyme, requiring extended peptide substrates containing an Asp residue....