Daily Changes in Composition and Diversity of the Intestinal Microbiota in Patients with Anorexia Nervosa: A Series of Three Cases

Overview

Journal Eur Eat Disord Rev

Publisher Wiley

Specialty Nutritional Sciences

Date 2017 Jun 7

PMID 28586130

Citations 26

Authors

Susan C Kleiman

Elaine M Glenny

Emily C Bulik-Sullivan

Eun Young Huh

Matthew C B Tsilimigras

Anthony A Fodor

Cynthia M Bulik

Ian M Carroll

Affiliations

Soon will be listed here.

Abstract

Anorexia nervosa, a severe psychiatric illness, is associated with an intestinal microbial dysbiosis. Individual microbial signatures dominate in healthy samples, even over time and under controlled conditions, but whether microbial markers of the disorder overcome inter-individual variation during the acute stage of illness or renourishment is unknown. We characterized daily changes in the intestinal microbiota in three acutely ill patients with anorexia nervosa over the entire course of hospital-based renourishment and found significant, patient-specific changes in microbial composition and diversity. This preliminary case series suggests that even in a state of pathology, individual microbial signatures persist in accounting for the majority of intestinal microbial variation. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

Citing Articles

The Role of the Gut Microbiota in Anorexia Nervosa in Children and Adults-Systematic Review.

Anton-Paduraru D, Trofin F, Nastase E, Miftode R, Miftode I, Trandafirescu M Int J Mol Sci. 2024; 25(1).

PMID: 38203211 PMC: 10779038. DOI: 10.3390/ijms25010041.

A consortia of clinical E. coli strains with distinct in vitro adherent/invasive properties establish their own co-colonization niche and shape the intestinal microbiota in inflammation-susceptible mice.

Bleich R, Li C, Sun S, Ahn J, Dogan B, Barlogio C Microbiome. 2023; 11(1):277.

PMID: 38124090 PMC: 10731797. DOI: 10.1186/s40168-023-01710-y.

Persistence of gut dysbiosis in individuals with anorexia nervosa.

Morisaki Y, Miyata N, Nakashima M, Hata T, Takakura S, Yoshihara K PLoS One. 2023; 18(12):e0296037.

PMID: 38117788 PMC: 10732397. DOI: 10.1371/journal.pone.0296037.

Gut Microbial Changes Following Fecal Microbiota Transplantation for D-Lactic Acidosis in Two Children.

Busing J, Fouladi F, Bulik-Sullivan E, Carroll I, Fodor A, Thomsen K JPGN Rep. 2023; 4(3):e319.

PMID: 37600604 PMC: 10435018. DOI: 10.1097/PG9.0000000000000319.

Associations of Dietary Intake with the Intestinal Microbiota and Short-Chain Fatty Acids Among Young Adults with Type 1 Diabetes and Overweight or Obesity.

Igudesman D, Crandell J, Corbin K, Hooper J, Thomas J, Bulik C J Nutr. 2023; 153(4):1178-1188.

PMID: 36841667 PMC: 10356993. DOI: 10.1016/j.tjnut.2022.12.017.

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