Persistence of Gut Dysbiosis in Individuals with Anorexia Nervosa

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2023 Dec 20

PMID 38117788

Authors

Yukiko Morisaki

Noriyuki Miyata

Megumi Nakashima

Tomokazu Hata

Shu Takakura

Kazufumi Yoshihara

Takafumi Suematsu

Koji Nomoto

Kouji Miyazaki

Hirokazu Tsuji

Nobuyuki Sudo

Affiliations

Soon will be listed here.

Abstract

Recent evidence suggests a crucial role of the gut microbiota in the pathogenesis of anorexia nervosa (AN). In this study, we carried out a series of multiple analyses of the gut microbiota of hospitalized individuals with AN over three months using 16S or 23S rRNA-targeted reverse transcription-quantitative polymerase chain reaction (PCR) technology (YIF-SCAN®), which is highly sensitive and enables the precise quantification of viable microorganisms. Despite the weight gain and improvements in psychological features observed during treatment, individuals with AN exhibited persistent gut microbial dysbiosis over the three-month duration. Principal component analysis further underscored the distinct microbial profile of individuals with AN, compared with that of age-matched healthy women at all time points. Regarding the kinetics of bacterial detection, the detection rate of Lactiplantibacillus spp. significantly increased after inpatient treatment. Additionally, the elevation in the Bifidobacterium counts during inpatient treatment was significantly correlated with the subsequent body weight gain after one year. Collectively, these findings suggest that gut dysbiosis in individuals with AN may not be easily restored solely through weight gain, highlighting the potential of therapeutic interventions targeting microbiota via dietary modifications or live biotherapeutics.

Citing Articles

Cytokine and Microbiome Changes in Adolescents with Anorexia Nervosa at Admission, Discharge, and One-Year Follow-Up.

Kaver L, Voelz C, Specht H, Thelen A, Keller L, Dahmen B Nutrients. 2024; 16(11).

PMID: 38892530 PMC: 11174589. DOI: 10.3390/nu16111596.

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