Multi-omics Approaches to Disease

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2017 May 7

PMID 28476144

Citations 905

Authors

Yehudit Hasin

Marcus Seldin

Aldons Lusis

Affiliations

Soon will be listed here.

Abstract

High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which gave rise to the field of "integrative genetics". Other omics technologies, such as proteomics and metabolomics, are now often incorporated into the everyday methodology of biological researchers. In this review, we provide an overview of such omics technologies and focus on methods for their integration across multiple omics layers. As compared to studies of a single omics type, multi-omics offers the opportunity to understand the flow of information that underlies disease.

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