Catalytic Synthesis of N-Heterocycles Via Direct C(sp)-H Amination Using an Air-Stable Iron(III) Species with a Redox-Active Ligand

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2017 Mar 17

PMID 28298089

Citations 33

Authors

Bidraha Bagh

Daniel L J Broere

Vivek Sinha

Petrus F Kuijpers

Nicolaas P van Leest

Bas de Bruin

Serhiy Demeshko

Maxime A Siegler

Jarl Ivar van der Vlugt

Affiliations

Soon will be listed here.

Abstract

Coordination of FeCl to the redox-active pyridine-aminophenol ligand NNO in the presence of base and under aerobic conditions generates FeCl(NNO) (1), featuring high-spin Fe and an NNO radical ligand. The complex has an overall S = 2 spin state, as deduced from experimental and computational data. The ligand-centered radical couples antiferromagnetically with the Fe center. Readily available, well-defined, and air-stable 1 catalyzes the challenging intramolecular direct C(sp)-H amination of unactivated organic azides to generate a range of saturated N-heterocycles with the highest turnover number (TON) (1 mol% of 1, 12 h, TON = 62; 0.1 mol% of 1, 7 days, TON = 620) reported to date. The catalyst is easily recycled without noticeable loss of catalytic activity. A detailed kinetic study for C(sp)-H amination of 1-azido-4-phenylbutane (S) revealed zero order in the azide substrate and first order in both the catalyst and BocO. A cationic iron complex, generated from the neutral precatalyst upon reaction with BocO, is proposed as the catalytically active species.

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