Ligand-free Iron-catalyzed Benzylic C (sp)-H Amination of Methylarenes with -fluorobenzenesulfonimide

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 9

PMID 35530456

Authors

Fengyu Bao

Yuanbo Cao

Wenbo Liu

Junhao Zhu

Affiliations

Soon will be listed here.

Abstract

Direct conversion of cheap methylarenes to benzylic amines, which are essential structural units of important drugs, is of great significance. However, the known methodologies suffer from the requirement of noble metal catalysts, heavy metal residues or strong oxidants. Herein, the first biocompatible iron-catalyzed benzylic C (sp)-H amination of methylarenes with -fluorobenzenesulfonimide is described. The reactions of methylarenes bearing electron-donating groups and electron-withdrawing groups ran smoothly under ligand and additional oxidant free conditions. Both toluene derivatives and 8-methylquinoline can be aminated by the same iron catalyst.

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