Silver Catalyzed Site-Selective C(sp)-H Bond Amination of Secondary over Primary C(sp)-H Bonds

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Oct 14

PMID 36234711

Authors

Luzhen Jiao

Dawei Teng

Zixuan Wang

Guorui Cao

Affiliations

Soon will be listed here.

Abstract

Sulfamates are widespread in numerous pharmacologically active molecules. In this paper, Silver/Bathophenanthroline catalyzed the intramolecular selective amination of primary C(sp)-H bonds and secondary C(sp)-H bonds of sulfamate esters, to produce cyclic sulfamates in good yields and with a high site-selectivity. DFT calculations revealed that the interaction between sulfamates and makes the molecule more firmly attached to the catalyst, benefiting the catalysis reaction. The in vitro anticancer activity of the final products was evaluated in MCF-7 breast cancer cells.

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