Cobalt(II)-catalyzed Intramolecular C-H Amination with Phosphoryl Azides: Formation of 6- and 7-membered Cyclophosphoramidates

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2010 Feb 27

PMID 20184343

Citations 32

Authors

Hongjian Lu

Jingran Tao

Jess E Jones

Lukasz Wojtas

X Peter Zhang

Affiliations

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Abstract

A highly effective Co(II)-based system has been developed for catalytic intramolecular C-H amination with phosphoryl azides without the need of terminal oxidant or other additives, resulting in the high-yielding production of cyclophosphoramidates with nitrogen gas as the byproduct. Additional features of this new catalytic system include the amination of primary C-H bonds and formation of 7-membered-ring structures.

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