Zhiyuan Ke
Overview
Explore the profile of Zhiyuan Ke including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
385
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0
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Recent Articles
1.
Vankadara S, Ke Z, Wang S, Foo S, Gunaratne J, Lee M, et al.
Chem Biol Drug Des
. 2024 Apr;
103(4):e14516.
PMID: 38618710
Ovarian cancer is the most deadly female gynaecological malignancy in developed countries and new treatments are urgently needed. The luteinising hormone releasing hormone (LHRH) peptide drug conjugate Zoptarelin doxorubicin is...
2.
Loh Y, Anantharajan J, Huang Q, Xu W, Fulwood J, Ng H, et al.
Protein Sci
. 2024 Feb;
33(3):e4904.
PMID: 38358126
UBE2T is an attractive target for drug development due to its linkage with several types of cancers. However, the druggability of ubiquitin-conjugating E2 (UBE2T) is low because of the lack...
3.
Anantharajan J, Tan Q, Fulwood J, Sifang W, Huang Q, Ng H, et al.
Biochem Biophys Res Commun
. 2023 Nov;
689:149238.
PMID: 37979329
UBE2T is an E2 ubiquitin ligase critical for ubiquitination of substrate and plays important roles in many diseases. Despite the important function, UBE2T is considered as an undruggable target due...
4.
Huang Q, Ng H, Loh Y, Ke Z, Lim W, Kang C
Biomol NMR Assign
. 2023 Sep;
17(2):269-274.
PMID: 37773242
Ubiquitin-conjugating enzyme E2 T (UBE2T) plays important roles in ubiquitination of proteins through participation in transferring ubiquitin to its substrate. Due to its importance in protein modifications, UBE2T associates with...
5.
Ng P, Foo K, Sim S, Wang G, Huang C, Tan L, et al.
Bioorg Med Chem
. 2021 Oct;
49:116437.
PMID: 34600239
AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor...
6.
Huang C, Liew S, Lin G, Poulsen A, Ang M, Chia B, et al.
ACS Med Chem Lett
. 2019 Aug;
10(8):1240.
PMID: 31413812
[This corrects the article DOI: 10.1021/acsmedchemlett.9b00170.].
7.
Huang C, Liew S, Lin G, Poulsen A, Ang M, Chia B, et al.
ACS Med Chem Lett
. 2019 Jun;
10(6):978-984.
PMID: 31223458
SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent...
8.
Ho S, Alam J, Jeyaraj D, Wang W, Lin G, Ang S, et al.
J Med Chem
. 2017 Jul;
60(15):6678-6692.
PMID: 28671458
Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers. Consequently porcupine inhibitors are thought to be promising...
9.
Madan B, Ke Z, Lei Z, Oliver F, Oshima M, Lee M, et al.
Oncotarget
. 2016 Feb;
7(11):12386-92.
PMID: 26848981
Activation of Wnt signaling due to Wnt overexpression or mutations of Wnt pathway components is associated with various cancers. Blocking Wnt secretion by inhibiting PORCN enzymatic activity has shown efficacy...
10.
Duraiswamy A, Lee M, Madan B, Ang S, Tan E, Cheong W, et al.
J Med Chem
. 2015 Jun;
58(15):5889-99.
PMID: 26110200
Wnt proteins regulate various cellular functions and serve distinct roles in normal development throughout life. Wnt signaling is dysregulated in various diseases including cancers. Porcupine (PORCN) is a membrane-bound O-acyltransferase...