Yoshitami Hashimoto
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Explore the profile of Yoshitami Hashimoto including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
1073
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0
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Recent Articles
1.
Hashimoto Y, Sadano K, Miyata N, Ito H, Tanaka H
EMBO J
. 2023 Jul;
42(17):e114131.
PMID: 37458194
CMG (Cdc45-MCM-GINS) helicase assembly at the replication origin is the culmination of eukaryotic DNA replication initiation. This process can be reconstructed in vitro using defined factors in Saccharomyces cerevisiae; however,...
2.
Hashimoto Y, Tanaka H
Life Sci Alliance
. 2022 Mar;
5(6).
PMID: 35292537
Mre11 is a versatile exo-/endonuclease involved in multiple aspects of DNA replication and repair, such as DSB end processing and checkpoint activation. We previously demonstrated that forced mitotic entry drives...
3.
Hashimoto Y, Tanaka H
J Biol Chem
. 2020 Nov;
296:100033.
PMID: 33148697
DNA replication is a major contributor to genomic instability, and protection against DNA replication perturbation is essential for normal cell division. Certain types of replication stress agents, such as aphidicolin...
4.
Hashimoto Y, Tanaka H
Biochem Biophys Res Commun
. 2018 Oct;
506(1):108-113.
PMID: 30340827
The disassembly of eukaryotic replisome during replication termination is mediated by CRL-dependent poly-ubiquitylation of Mcm7 and p97 segregase. The replisome also disassembles at stalled or collapsed replication forks under certain...
5.
Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen K, Fachinetti D, Bermejo R, et al.
Nat Struct Mol Biol
. 2012 Mar;
19(4):417-23.
PMID: 22388737
Topoisomerase I (Top1) releases torsional stress during DNA replication and transcription and is inhibited by camptothecin and camptothecin-derived cancer chemotherapeutics. Top1 inhibitor cytotoxicity is frequently linked to double-strand break (DSB)...
6.
Hashimoto Y, Puddu F, Costanzo V
Nat Struct Mol Biol
. 2011 Dec;
19(1):17-24.
PMID: 22139015
In higher eukaryotes, the dynamics of replisome components during fork collapse and restart are poorly understood. Here we have reconstituted replication fork collapse and restart by inducing single-strand DNA lesions...
7.
Hashimoto Y, Costanzo V
Methods Mol Biol
. 2011 Jun;
745:437-45.
PMID: 21660709
A crucial process to ensure cell survival and genome stability is the correct replication of the genome. DNA replication relies on complex machinery whose mechanisms are being elucidated using different...
8.
Hashimoto Y, Ray Chaudhuri A, Lopes M, Costanzo V
Nat Struct Mol Biol
. 2010 Oct;
17(11):1305-11.
PMID: 20935632
The role of Rad51 in an unperturbed cell cycle has been difficult to distinguish from its DNA repair function. Here, using EM to visualize replication intermediates assembled in Xenopus laevis...
9.
Hashimoto Y, Tsujimura T, Sugino A, Takisawa H
Genes Cells
. 2006 Aug;
11(9):993-1007.
PMID: 16923121
ATR-dependent activation of the kinase Chk1 is the initial step in signal transduction in the DNA replication checkpoint, which allows a cell to enter mitosis only after the completion of...
10.
Matsuno K, Kumano M, Kubota Y, Hashimoto Y, Takisawa H
Mol Cell Biol
. 2006 Jun;
26(13):4843-52.
PMID: 16782873
Recruitment of DNA polymerases onto replication origins is a crucial step in the assembly of eukaryotic replication machinery. A previous study in budding yeast suggests that Dpb11 controls the recruitment...